Invasive Pituitary Adenoma with Abscess Formation

Zorub, D S; Martinez, A. J.; Nelson, Paul B.; Lam, M. Tai

doi:10.1227/00006123-197912000-00014

Cited by 35 publications

(11 citation statements)

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“…8,13) Glioma with abscess formation is extremely rare, and few cases have been described. [1][2][3]5,7,[9][10][11][12] Guidelines for the treatment of gliomas complicated by intratumoral abscesses have thus not been determined.…”

Section: Introductionmentioning

confidence: 99%

Glioblastoma Associated With Intratumoral Abscess Formation

Tsugu

Osada

Nishiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Section: Introductionmentioning

confidence: 99%

Glioblastoma Associated With Intratumoral Abscess Formation

Tsugu

Osada

Nishiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…6,8,9,11 Some authors suggested that the tumor vulnerability to infection probably depends on impaired circulation, areas of necrosis, and local immunological impairment. 2,3,6 The infection is caused either by hematogenous seeding of the pituitary gland or by direct extension of an adjacent infection.…”

Section: Discussionmentioning

confidence: 99%

Pituitary Abscess Presenting a Very Rapid Progression

Kotani

Abiru

Miyao

et al. 2012

The American Journal of Forensic Medicine and Pathology

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Pituitary abscess is a rare disease presenting with nonspecific clinical symptoms, and diagnosis is often difficult. This disease is potentially life-threatening, but most cases have a chronic and indolent course. We report a case of a 60-year-old man with a pituitary abscess associated with pituitary adenoma who died 5 days after the onset of clinical symptoms without a definitive diagnosis. Postmortem computed tomography and autopsy findings revealed a sellar mass with cystic change and extension toward the optic chiasm. Histopathology of the lesion demonstrated an abscess with suppurative meningitis and encephalitis. The disturbance of the cardiac autonomic nervous system because of hypothalamus involvement was suggested as the cause of rapid progression and death. This case provides useful information for clinicians to avoid a lethal outcome.

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“…11,18 Since the invention of antibiotics, pituitary abscess has become a treatable disease. Early surgical drainage of the abscess by transsphenoidal surgery and long-term administration of antibiotics are the standard treatment 31 and have raised the survival rate to 85%. 31 A long period of follow-up is also required since the potential for recurrence remains even 7 years after surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…Early surgical drainage of the abscess by transsphenoidal surgery and long-term administration of antibiotics are the standard treatment 31 and have raised the survival rate to 85%. 31 A long period of follow-up is also required since the potential for recurrence remains even 7 years after surgical resection. 7 Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis are successfully treated by administration of glucocorticoids, with or without delayed surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

A Patient Presenting Partial Diabetes Insipidus Diagnosed as Pituitary Abscess With Paranasal Sinusitis

Matsuno¹,

Nakashima²,

Katayama³

et al. 2005

The Endocrinologist

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Pituitary abscess is a rare clinicopathological entity. Although many cases of pituitary abscess have been reported, the origin, etiology, and nature of this condition remain enigmatic. Furthermore, despite remarkable advances in medical technology, preoperative and histopathological diagnosis remains difficult. In this report, we described a 60-year-old patient with pituitary abscess presenting partial diabetes insipidus with paranasal sinusitis and focused on the necessity of surgical exploration of the surrounding pituitary tissue and histopathological confirmation for the precise diagnosis. Prolonged administration of antibiotics is recommended. (The Endocrinologist 2005;15: 10 -13)P ituitary abscess is a rare clinicopathological entity. Although over 200 cases of pituitary abscess have been reported since the early 19th century, the origin, etiology, and nature of this condition remain enigmatic. Furthermore, despite remarkable advances in medical technology, preoperative and histopathological diagnosis remains difficult. In this report, we described a patient of pituitary abscess presenting partial diabetes insipidus with paranasal sinusitis and focused on the necessity of surgical exploration and histopathological confirmation for the precise diagnosis. CASE REPORTA 60-year-old man complained of headache, thirst, polydipsia, and polyuria since August 2002. He was found to have a mass lesion in the pituitary gland and was admitted to our hospital on September 25, 2002. His urinary volume was 5800 to 6600 mL per day. He had a history of bilateral maxillary sinusitis. He was afebrile and free from visual symptoms, except for decreased visual acuity in the right eye due to cataract. General and neurologic examination revealed no abnormality; his body height was 161 cm, body weight 75 kg, blood pressure 140/70 mm Hg. Routine blood tests were normal; white blood cell count 5300, C-reactive protein (CRP) Ͻ0.3. Basal levels of pituitary and its related hormones were within normal values as follows: growth hormone (GH) 0.26 ng/mL (normal range: Ͻ0.42 ng/mL), prolactin (PRL) 4.3 ng/mL (1.5-9.7 ng/mL), luteinizing hormone (LH) 1.1 mIU/mL (0.2-20 mIU/mL) and folliculostimulating hormone (FSH) 3.8 mIU/mL (0.8-22.9 mIU/mL). His plasma adrenocorticotropic hormone (ACTH) and serum cortisol levels were normal, being 11.4 pg/mL (4-40 pg/mL) and 9.4 g/dL (4.0-18.3 g/dL), respectively. Serum TSH was 2.4 U/mL (0.34-3.5 U/mL), and free T4 and free T3 were 0.99 ng/dL (0.83-1.56 ng/dL) and 2.79 pg/mL (2.38-4.23 pg/mL), respectively. Intravenous injection of 500 g of thyrotropin releasing hormone increased serum TSH and PRL from 2.4 U/mL to 13.2 U/mL, from 5.5 ng/mL to 14.0 ng/mL; 100 g of gonadotropin releasing hormone loading increased serum FSH and LH from 3.2 mIU/mL to 10.0 mIU/mL, from 0.9 mIU/mL to 11.0 mIU/mL. One hundred micrograms of GH releasing hormone loading increased serum GH from 0.33 ng/mL to 15.2 ng/mL. One hundred micrograms of corticotropin releasing hormone loading increased plasma ACTH and serum cortisol from ...

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Invasive Pituitary Adenoma with Abscess Formation

Cited by 35 publications

References 0 publications

Glioblastoma Associated With Intratumoral Abscess Formation

Glioblastoma Associated With Intratumoral Abscess Formation

Pituitary Abscess Presenting a Very Rapid Progression

A Patient Presenting Partial Diabetes Insipidus Diagnosed as Pituitary Abscess With Paranasal Sinusitis

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