Invasive mucormycosis affecting maxillofacial region in oncohematological patients undergoing chemotherapeutic treatment and transplantation of hematopoietic stem cells

Baranova, Irina B.; Popova, M.; Yaremenko, A.I.; Zubkova, N V; Пинегина, О Н; Nikolaev, I.

doi:10.17116/stomat202210102180

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Mainly, the genera of Absidia , Mucor , Rhizomucor , and Rhizopus are responsible for its aetiology, although Apophysomyces , Cunninghamella , and Saksenaea can also be associated pathogenic species [ 2 , 3 ]. It is an uncommon, rapidly emerging infection of fungi, with high morbidity and mortality that can produce widespread oral-maxillofacial tissue necrosis [ 4 , 5 ]. Due to the rarity of this disease (especially occurred in craniofacial units), it is almost impossible to conduct multicentric and randomized clinical trials with large sample size; hence, most of the existent data in respect of epidemiological characteristics, diagnostic strategy, and therapeutic decision-making originate from case series and case reports.…”

Section: Introductionmentioning

confidence: 99%

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

Gong

Pataer

et al. 2023

BMC Oral Health

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Purpose Mucormycosis is a type of fatal infectious disease, rarely involved in the oromaxillofacial region. This study aimed to describe a series of 7 cases with oromaxillofacial mucormycosis and to discuss the epidemiology, clinical features, and treatment algorithm thereof. Methodology Seven patients in the author’s affiliation have been treated. They were assessed and presented as per their diagnostic criteria, surgical approach, and mortality rates. Reported cases of mucormycosis originally happened in craniomaxillofacial region were synthesized through a systematic review so as to better discuss its pathogenesis, epidemiology, and management. Results Six patients had a primary metabolic disorder, and one immunocompromised patient had a history of aplastic anemia. The criteria for a positive diagnosis of invasive mucormycosis were based on clinical presentation of signs and symptoms, and a biopsy for microbiological culture and histopathologic analysis. Each patient used antifungal drugs and five of them also underwent surgical resection at the same time. Four patients died due to the unregulated spread of mucormycosis, and one patient died owing to her main disease. Conclusions Although uncommon in clinical practice setting, mucormycosis should be of great concern in oral and maxillofacial surgery, due to the life-threatening possibility of this disease. The knowledge of early diagnosis and prompt treatment is of utmost importance for saving lives.

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Section: Introductionmentioning

confidence: 99%

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

Gong

Pataer

et al. 2023

BMC Oral Health

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Postcovid necrosis of the cranio-maxillofacial region

Ivanyuta¹,

Hristoforando

Spevak

et al. 2023

Kazan Med J

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The review article is devoted to one of the new topical problems in medicine necrosis of the organs of the cranio-maxillofacial region in patients with coronavirus infection, which was first discussed at the end of 2020. Later, doctors of various specialties (otolaryngologists, ophthalmologists, maxillofacial surgeons, neurosurgeons, dentists) from many countries of the world met in their practice with inflammatory-necrotic lesions of the mucous membrane of the nasal cavity and paranasal sinuses, facial skeleton and skull, eyeball, brain. The article highlights the main points of view of scientists about the etiology and pathogenesis of the studied pathology. Summarized data from the largest studies on the epidemiology, risk factors, and symptoms of post-covid necrosis of the cranio-maxillofacial region are presented. The results of various methods for diagnosing this complication multislice computed tomography, magnetic resonance imaging, angiography, are described in detail. Due to the fact that today the role of fungal flora is recognized as the leading one in the etiology of post-covid necrosis of the cranio-maxillofacial region, much attention is paid to cytological, microbiological and pathohistological research methods, which should be aimed at the search for mycelium. The main approaches to the treatment of patients with this pathology are formulated. The article highlights issues important for practical healthcare: interpretation of national clinical guidelines for coronavirus infection in terms of post-covid necrosis of the cranio-maxillofacial region, classification options according to the International Classification of Diseases of the 10th revision, the procedure for providing medical care to this category of patients, the economic consequences of the lack of active prevention methods of the presented complication in patients with COVID-19.

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Invasive mucormycosis affecting maxillofacial region in oncohematological patients undergoing chemotherapeutic treatment and transplantation of hematopoietic stem cells

Cited by 2 publications

References 7 publications

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

Postcovid necrosis of the cranio-maxillofacial region

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