Invasive micropapillary carcinoma of the mammary glands in a mare

Gamba, Conrado de Oliveira; Araújo, Marina Rios de; Palhares, Maristela Silveira; Garbin, L.C.; Maranhão, Raul C.; Cassali, Geovanni Dantas; Ecco, Roselene

doi:10.1080/01652176.2011.642618

Cited by 9 publications

(14 citation statements)

References 24 publications

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“…Histologically, equine primary malignant mammary tumors have been diagnosed as ductal carcinomas [9], solid carcinomas [7,16,17], tubulo-papillary carcinomas [18], papillary ductal adenocarcinomas [14,19,20], or a combination of tubulo-papillary and solid carcinomas [10]. Only one case of micropapillary in situ carcinoma was reported [8]. In our case, the microscopic features of the tumor were the same as those reported in the literature for solid carcinomas.…”

Section: Discussionsupporting

confidence: 73%

“…Previous IHC investigations on equine mammary carcinomas generally showed a mild to moderate immunostaining for panCK [10], as reported in our case, highlighting the simple epithelial nature of these lesions in horses. Furthermore, a high proportion (9/13) of mammary tumors in horses are negative or only weakly positive (less than 5% of the neoplastic cells) for the expression of steroid receptors [8,10,12,14,18]. Only 4 out of 13 samples of equine mammary tumors reported so far exhibited convincing ER positivity [8,10,12,14,18], and only one case, to our knowledge, was found positive for both ER and PR [8].…”

Section: Discussionmentioning

confidence: 79%

“…Mammary neoplasms in mares are considered a rare event, usually documented via case reports [7][8][9] or small case series [10], with less than 30 tumors reported so far (prevalence rate of 0.11%) [11]. They are usually malignant, with the unique case of a benign adenoma reported by Spadari and colleagues in 2008 [12].…”

Section: Discussionmentioning

confidence: 99%

“…The majority of equine mammary carcinomas result in high metastatic spread to lymph nodes and visceral organs [8,9,[14][15][16][18][19][20], but no previous reports of cerebellar, cardiac, and subcutaneous metastases are present in the literature. In our case, the metastatic behavior of the neoplasia appeared particularly aggressive, and the metastatic lesions appeared more anaplastic, in line with what was previously reported by Kato and colleagues in 1998 [21].…”

Section: Discussionmentioning

confidence: 99%

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Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

Brocca

Centelleghe

Padoan³

et al. 2020

Animals

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A 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. Subsequently, the mare was presented with rapidly spreading multiple subcutaneous masses and, at the onset of neurological signs, was humanely euthanized and subjected to a complete post mortem examination. The necropsy confirmed the presence of numerous widespread masses in the subcutaneous tissue, several internal organs, and mammary gland. Histological and immunohistochemical (IHC) examinations were performed on all masses, allowing the diagnosis of mammary carcinoma with several visceral and subcutaneous metastases. Considering the post mortem findings, the second intraocular mass was submitted to histological and IHC re-evaluation to differentiate it from an intraocular metastasis of the mammary carcinoma. The results of the histological and IHC analyses confirmed the diagnosis of neuroepithelial tumor relapse. This is the first case of a metastatic mammary carcinoma concurrent with a recurrent intraocular neuroepithelial tumor in a mare. This case was a challenge for both clinicians and pathologists involved and highlighted the importance of post mortem and IHC evaluations.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

Brocca

Centelleghe

Padoan³

et al. 2020

Animals

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“…Notably, a number of specific morphological variants described for feline and canine mammary tumours have been described in horses. For example, invasive micropapillary carcinoma [138] and ductal carcinoma [28] have both been documented.…”

Section: Histopathological and Molecular Analysesmentioning

confidence: 99%

Development and Pathology of the Equine Mammary Gland

Hughes

2020

J Mammary Gland Biol Neoplasia

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An understanding of the anatomy, histology, and development of the equine mammary gland underpins study of the pathology of diseases including galactorrhoea, agalactia, mastitis, and mammary tumour development. This review examines the prenatal development of the equine mammary gland and the striking degree to which the tissue undergoes postnatal development associated with the reproductive cycle. The gland is characterised by epithelial structures arranged in terminal duct lobular units, similar to those of the human breast, supported by distinct zones of intra- and interlobular collagenous stroma. Mastitis and mammary carcinomas are two of the most frequently described equine mammary pathologies and have an overlap in associated clinical signs. Mastitis is most frequently associated with bacterial aetiologies, particularly Streptococcus spp., and knowledge of the process of post-lactational regression can be applied to preventative husbandry strategies. Equine mammary tumours are rare and carry a poor prognosis in many cases. Recent studies have used mammosphere assays to reveal novel insights into the identification and potential behaviour of mammary stem/progenitor cell populations. These suggest that mammospheres derived from equine cells have different growth dynamics compared to those from other species. In parallel with studying the equine mammary gland in order to advance knowledge of equine mammary disease at the interface of basic and clinical science, there is a need to better understand equine lactational biology. This is driven in part by the recognition of the potential value of horse and donkey milk for human consumption, particularly donkey milk in children with ‘Cow Milk Protein Allergy’.

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Other epithelial neoplasms

Knottenbelt

2015

Clinical Equine Oncology

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Invasive micropapillary carcinoma of the mammary glands in a mare

Cited by 9 publications

References 24 publications

Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

Development and Pathology of the Equine Mammary Gland

Other epithelial neoplasms

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