Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015

Pérez‐Nadales, Elena; Alastruey‐Izquierdo, Ana; Linares-Sicilia, María José; Soto-Debrán, Juan Carlos; Abdala, Edson; García-Rodríguez, Julio; Montejo, Miguel; Muñóz, Patricia; Lletí, Miguel Salavert; Rezusta, Antonio; Pipaón, Maite Ruiz Pérez de; Yáñez, Lucrecia; Merino, Esperanza; Campos-Herrero, María Isolina; Costa-Mateo, José María; Fortün, Jesús; García-Lozano, Tomás; García-Vidal, Carolina; Fernández‐Ruiz, Mario; Sánchez-Reus, Ferran; Castro-Méndez, Carmen; Guerrero-Lozano, Inmaculada; Soler‐Palacín, Pere; Aguado, José María; Martı́nez-Martı́nez, Luis; Torre-Cisneros, J; Nucci, Márcio

doi:10.3201/eid2701.190782

Cited by 20 publications

(23 citation statements)

References 31 publications

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“…The main results are presented in Table 1. The majority of isolates were distributed within three SCs, namely, the Fusarium oxysporum SC (FOSC), the Fusarium fujikuroi SC (FFSC), and the Fusarium solani SC (FSSC), reflecting the epidemiology of human fusariosis (7,8). As expected, Fusarium spp.…”

mentioning

confidence: 55%

Antifungal Susceptibility of 182 Fusarium Species Isolates from 20 European Centers: Comparison between EUCAST and Gradient Concentration Strip Methods

Normand

Imbert

Al‐Hatmi

et al. 2021

Antimicrob Agents Chemother

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We determined the susceptibility of 182 Fusarium spp. isolates to 5 antifungal drugs (amphotericin B, voriconazole, posaconazole, isavuconazole, terbinafine) by EUCAST method. Based on the latest taxonomic insights, isolates collected from 20 European centers were distributed into 7 complexes and 27 species. The susceptibility was variable depending on the species. Comparison with gradient concentration strips method performed for 77 isolates showed essential agreement for voriconazole, posaconazole, isavuconazole and amphotericin B of 17%, 91%, 83% and 70%, respectively.

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mentioning

confidence: 55%

Antifungal Susceptibility of 182 Fusarium Species Isolates from 20 European Centers: Comparison between EUCAST and Gradient Concentration Strip Methods

Normand

Imbert

Al‐Hatmi

et al. 2021

Antimicrob Agents Chemother

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“…Among the 44 neutropenic patients, 41 (93.2%) had a hematologic condition compared to 5 of 14 (35.7%) among those who were non-neutropenic. In three of the latter five patients, the infection developed after allogeneic HCT given for a hematologic disease [28].…”

Section: Settingmentioning

confidence: 95%

“…As shown in Table 2, the incidence of invasive fusariosis in patients with hematologic diseases varies across different regions of the globe with the highest incidence reported in Brazil, compared with other countries such as Italy, USA, and Spain [1,12,[28][29][30][31][32][33][34][35].…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%

Invasive Fusariosis in Patients with Hematologic Diseases

Nucci

Barreiros

Akiti

et al. 2021

JoF

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Fusarium species are filamentous fungi widely encountered in nature, and may cause invasive disease in patients with hematologic conditions. Patients at higher risk are those with acute leukemia receiving induction remission chemotherapy or allogeneic hematopoietic cell transplant recipients. In these hosts, invasive fusariosis presents typically with disseminated disease, fever, metastatic skin lesions, pneumonia, and positive blood cultures. The prognosis is poor and the outcome is largely dependent on the immune status of the host, with virtually a 100% death rate in persistently neutropenic patients, despite monotherapy or combination antifungal therapy. In this paper, we will review the epidemiology, clinical manifestations, diagnosis, and management of invasive fusariosis affecting patients with hematologic diseases.

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“…Previous studies also showed a high mortality rate, which ranged from 60% to 80% at 90 days or 12 weeks. 5,6,25 The cause of relatively lower mortality rate in our study may be due to different characteristics of patients. There were fewer patients with haematologic malignancy (62%) than in other studies (80-92%), and more solid organ transplantation recipients (23%) in our study than in others.…”

Section: Ta B L Ementioning

confidence: 73%

“…There were fewer patients with haematologic malignancy (62%) than in other studies (80-92%), and more solid organ transplantation recipients (23%) in our study than in others. 5,25 This study has several limitations. First, this was a single-centre retrospective study with a small sample size.…”

Section: Ta B L Ementioning

confidence: 96%

Clinical characteristics and outcomes of invasive and non‐invasive fusariosis in South Korea

Park

Bae

Kim

et al. 2022

Mycoses

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Background Invasive fusariosis mainly affects immunocompromised patients including haematopoietic stem cell transplant recipients and those with haematologic malignancy. There are limited studies on invasive fusariosis in the Asia‐Pacific region. Objective To describe the clinical characteristics and outcomes of invasive and non‐invasive fusariosis in South Korea. Patients/Methods From 2005 to 2020, patients with fusariosis who met the revised European Organisation for Research and Treatment of Cancer and the Mycoses Study Group criteria for the definition of proven or probable invasive fusariosis, and those with non‐invasive fusariosis were retrospectively reviewed in a tertiary medical centre in Seoul, South Korea. Results Overall, 26 and 75 patients had invasive and non‐invasive fusariosis, respectively. Patients with invasive fusariosis commonly had haematologic malignancy (62%), were solid organ transplant recipients (23%), and had a history of immunosuppressant usage (81%). In non‐invasive fusariosis, diabetes mellitus (27%) and solid cancer (20%) were common underlying conditions. Disseminated fusariosis (54%) and invasive pulmonary disease (23%) were the most common clinical manifestations of invasive fusariosis; skin infection (48%) and keratitis (27%) were the most common manifestations of non‐invasive fusariosis. Twenty‐eight‐day and in‐hospital mortalities were high in invasive fusariosis (40% and 52%, respectively). In multivariate analysis, invasive fusariosis (adjusted odds ratio, 9.6; 95% confidence interval 1.3–70.8; p = .03) was an independent risk factor for 28‐day mortality. Conclusions Patients with invasive fusariosis were frequently immunocompromised, and more than half had disseminated fusariosis. Invasive fusariosis was associated with poor prognosis.

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Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015

Abstract: Invasive fusariosis has a global increasing incidence and has emerged as a severe infection in nonneutropenic patients.

Cited by 20 publications

References 31 publications

Antifungal Susceptibility of 182 Fusarium Species Isolates from 20 European Centers: Comparison between EUCAST and Gradient Concentration Strip Methods

Antifungal Susceptibility of 182 Fusarium Species Isolates from 20 European Centers: Comparison between EUCAST and Gradient Concentration Strip Methods

Invasive Fusariosis in Patients with Hematologic Diseases

Clinical characteristics and outcomes of invasive and non‐invasive fusariosis in South Korea

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