Invasive fungal diseases in patients with new diagnosed acute lymphoblastic leukaemia

Gründahl, Marie; Wacker, Beate; Einsele, Hermann; Heinz, Werner

doi:10.1111/myc.13151

Cited by 7 publications

(1 citation statement)

References 19 publications

(45 reference statements)

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“…IFD is more common in patients with acute myeloid leukemia than in those with acute lymphoblastic leukemia (ALL). However, a recent study had shown that despite the recent breathtaking development of antifungal drugs, patients of ALL with prolonged neutropenia were also associated with a higher risk of acquiring IFD ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: A rare case of pulmonary mucormycosis caused by Lichtheimia ramosa in pediatric acute lymphoblastic leukemia and review of Lichtheimia infections in leukemia

Liu²,

Zhang³

et al. 2022

Front. Oncol.

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Mucormycosis caused by Lichtheimia ramosa is an emerging and uncommon opportunistic infection in patients with hematological malignancies, with high mortality rates. Herein, we first report a case of pulmonary mucormycosis with Lichtheimia ramosa in a 3-year-old girl recently diagnosed with B-cell acute lymphoblastic leukemia. The diagnosis was made using computerized tomography of the lung, metagenomic next-generation sequencing (mNGS) of blood and sputum specimens, and microscopic examination to detect the development of Lichtheimia ramosa on the surgical specimen. She was effectively treated after receiving prompt treatment with amphotericin B and posaconazole, followed by aggressive surgical debridement. In our case, the fungal isolates were identified as Lichtheimia ramosa using mNGS, which assisted clinicians in quickly and accurately diagnosing and initiating early intensive treatment. This case also indicated the importance of strong clinical suspicion, as well as aggressive antifungal therapy combined with surgical debridement of affected tissues.

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Section: Introductionmentioning

confidence: 99%

Case report: A rare case of pulmonary mucormycosis caused by Lichtheimia ramosa in pediatric acute lymphoblastic leukemia and review of Lichtheimia infections in leukemia

Liu²,

Zhang³

et al. 2022

Front. Oncol.

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Co‐occurrence of rhino‐orbital mucormycosis and acute lymphoblastic leukemia post‐COVID‐19 infection in a young adolescent male: A case report from a low middle‐income country

Lingarapu,

Shaikh,

Singh

et al. 2024

Clinical Case Reports

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Key Clinical MessageImmunosuppression from B‐acute lymphoblastic leukemia (B‐ALL) chemotherapy and a preceding COVID‐19 infection may predispose patients to rare complications such as rhino‐orbital mucormycosis. Hence, a high index of suspicion should be maintained by physicians (and oncologists) if patients undergoing B‐ALL treatment present with orofacial symptoms and ophthalmological manifestations such as peri‐orbital swelling, ophthalmoplegia, and loss of vision, suggestive of infection.AbstractMucormycosis is a severe fungal infection that poses significant mortality and morbidity risks, particularly in immunocompromised individuals. We present a rare case of a 16‐year‐old patient with rhino‐orbital mucormycosis following B‐acute lymphoblastic leukemia (B‐ALL) treatment and concurrent COVID‐19 infection. We describe the clinical presentation, diagnosis, treatment, and outcome of this patient, and discuss the possible interactions and implications of these three conditions. A young 16‐year‐old male patient without significant clinical history was admitted with complaints of low‐grade intermittent fever, fatigue, malaise, restlessness, and unexplained weight loss for the past 2 months. A bone marrow biopsy confirmed the diagnosis of B‐ALL. Following the diagnosis of B‐ALL, the patient underwent initiation of chemotherapy. Following the initial two cycles of chemotherapy, the patient experienced fever and cough and tested positive for COVID‐19 infection. Nearly a week later, the patient presented to the chemotherapy emergency department with a clinical picture characterized by a fever up to 39°C associated with left facial swelling, severe headache, purulent rhinorrhea, and foreign body sensation in the ipsilateral nostril. The following day, erythema and left eyelid edema were observed, with ocular opening limitation. The diagnosis was confirmed based on the positive result of polymerase chain reaction for left‐sided mucormycosis. Initial administration of liposomal and lipid amphotericin B at 1–1.5 mg/kg/d doses for 4–6 weeks was followed by surgical debridement of necrotic tissue on the left side of the face and nose. Subsequent ophthalmological examinations showed normal conditions of the left eye. The case underscores the importance of heightened clinical suspicion, early diagnosis through imaging and molecular techniques, aggressive multimodal therapy, and close interdisciplinary collaboration for improved outcomes in such rare and challenging clinical scenarios.

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Aggressive disseminated Rhizomucor pusillus infection in a Ph-like acute lymphoblastic leukemia patient: Early detection by cell-free DNA next-generation sequencing

Shi¹,

Zhao²,

Yan³

et al. 2022

Journal of Infection and Chemotherapy

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Invasive fungal diseases in patients with new diagnosed acute lymphoblastic leukaemia

Cited by 7 publications

References 19 publications

Case report: A rare case of pulmonary mucormycosis caused by Lichtheimia ramosa in pediatric acute lymphoblastic leukemia and review of Lichtheimia infections in leukemia

Case report: A rare case of pulmonary mucormycosis caused by Lichtheimia ramosa in pediatric acute lymphoblastic leukemia and review of Lichtheimia infections in leukemia

Co‐occurrence of rhino‐orbital mucormycosis and acute lymphoblastic leukemia post‐COVID‐19 infection in a young adolescent male: A case report from a low middle‐income country

Aggressive disseminated Rhizomucor pusillus infection in a Ph-like acute lymphoblastic leukemia patient: Early detection by cell-free DNA next-generation sequencing

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