Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma

Sawair, Faleh; Irwin, Christopher; Gordon, Derek J.; Leonard, Alan G.; Stephenson, Mike; Napier, Séamus S.

doi:10.1034/j.1600-0714.2003.00060.x

Cited by 97 publications

(103 citation statements)

References 29 publications

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“…In 74 OSCC cases, there were 6, 8, 37 and 23 cases of patterns I, II, III and IV, respectively. As described in the literature, pattern IV has higher metastatic rate (Unal et al, 1999;Sawair et al, 2003). Interestingly, patterns I and II were completely negative for Periostin, in contrast with pattern IV, where all cases expressed Periostin ( Figure 2B).…”

Section: Resultssupporting

confidence: 70%

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Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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Oral squamous-cell carcinoma (OSCC) is one of the most common types of human cancer. Typically OSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the transcriptional profile of parent OSCC cell line and a highly invasive clone. Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines. To know the role of Periostin in invasion, angiogenesis and metastasis in OSCC cases, we first examined the expression of Periostin mRNA in 31 OSCC cases by RT -PCR and Periostin protein in 74 OSCC cases by immunohistochemistry. Then, we compared the Periostin expression with invasion pattern, metastasis and blood vessel density. Periostin mRNA and protein overexpression were frequently found in OSCC cases and Periostin expression was well correlated with the invasion pattern and metastasis. Moreover, blood vessel density of Periostin-positive cases was higher than those of Periostin-negative cases. Interestingly, recombinant Periostin enhanced capillary formation in vitro in a concentration-dependant manner. In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.

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Section: Resultssupporting

confidence: 70%

“…based on 3 wells data point in a single experiment. Tubule score was evaluated by the Chalkley count method (Sawair et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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“…Extended local invasion involves important surrounding structures, which makes it difficult to complete tumor resection and reduces cancer curability (19). Angiogenesis is a major event in the progression of OSCC, during which several angiogenic factors are recruited (10).…”

Section: Discussionmentioning

confidence: 99%

Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma

Suzuki

Shinohara

Rikiishi³

2008

Mol Med Report

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Abstract. Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis in oral squamous cell carcinoma (OSCC). In this study, we used the novel DNA methyltransferase inhibitor zebularine (Zeb) to investigate epigenetic influences on the secretion of VEGF-A in the OSCC cell line HSC-3. Under normoxic conditions, we found that Zeb inhibited secretion in a dose-dependent manner by reducing the activity of hypoxia-inducible factor-1α (HIF-1α). Treatment of the cells with the proteasome inhibitor MG132 protected the HIF-1α protein from Zeb-mediated epigenetic regulation. In addition, our study revealed that neither the PI3K/Akt nor the p53 signaling pathway is required for Zeb-induced HIF-1α degradation. In short, Zeb influenced the stability of the HIF-1α protein and the activity of its targets, such as VEGF, in HSC-3 cells in normoxic conditions. This study has laid the foundation for a novel anti-cancer approach, which may find applications in molecular staging.

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“…Could these models be used to predict which low-stage patients are at risk for disease-progression? Tumor pattern of invasion at the tumor host interface is a consistent component of these models [11][12][13][14][15][16][17][18][19][20]. Other components have included lymphocytic host response, exophytic versus endophytic growth pattern, mitotic rate, degree of keratinization, and nuclear pleomorphism.…”

Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

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Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma

Abstract: Grading of selected features in OSCC is reliable and can facilitate treatment planning.

Cited by 97 publications

References 29 publications

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

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