Invasive candidiasis in cancer patients: observations from a randomized clinical trial

DiNubile, Mark J.; Hille, Darcy A.; Sable, Carole A.; Kartsonis, Nicholas A.

doi:10.1016/j.jinf.2005.01.016

Cited by 46 publications

(39 citation statements)

References 35 publications

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“…Our patient population consisted of 60 individuals with seven different types of cancers. Gastro-intestinal cancer and Breast cancer were the most frequent cancer in the studied group, accounting for 65 % and 18.4 % respectively which is in accordance to other investigation [12]. Results obtained in this study established several points pertinent to the prevalence of oral candidiasis consistent with published data [13][14].…”

Section: Discussionsupporting

confidence: 91%

Oral <i>Candidiasis</i> amongst cancer patients at Qods Hospital

Afraseyabi¹,

Afkhamzadeh²,

Sabori³

et al. 2011

Af J Clin Exp Micro

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Background: Within the past two decades, Candida species have emerged as major human pathogens and are currently the fourth most common cause of nosocomial infection. Propose of this study was to determine the occurrence of oral Candidiasis among cancer patients at Qods hospitals in Sanandaj. Materials and Methods: Sixty cancer patients were examined for oral candidiasis. For all patients, the clinical diagnosis had to be confirmed microbiologically by the presence of yeasts and / or hyphae or pseudohyphae on potassium hydroxidetreated smears of oral swabs. Oral samples were obtained and cultured on Sabouraud's dextrose agar and CHROMagar. Results: 25 out of the 60 patients (41.7%) were males and 35 (58.3%) were females ranging in age from 15 to 79 years. Gastrointestinal cancer and Breast cancer were the most frequent cancer in the studied group, accounting for 65 % and 18.4 % respectively. The mean weight of the patients was 52.67 Kg (range,. Similarly, the mean of hospital stay was 3.58 days (range; 1-9 days). From these patients, 19 Candida spp were isolated; C. albicans alone outnumbered other species and accounted for 73.68% episodes of trash. For C. albicans isolates, the MIC values ranges from 1 to 9 µ g / ml µg / ml for polyenes and from 0.03 to 16 µ g / ml for the azole antifungals. All the Candida albicans had closely related MFCs values. Conclusion: In conclusions, the finding of our study strongly suggest that oral candidiasis is a frequent complication among cancer patients, being C. albicans the main etiological agent.

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Section: Discussionsupporting

confidence: 91%

Oral <i>Candidiasis</i> amongst cancer patients at Qods Hospital

Afraseyabi¹,

Afkhamzadeh²,

Sabori³

et al. 2011

Af J Clin Exp Micro

View full text Add to dashboard Cite

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“…In general, compared with patients with solid tumors, patients with hematologic malignancies are at increased risk for fungal disease and response to IFI treatment is lower [10]. A 1992 international autopsy survey of patients with cancer identified fungal infections in 25% of patients with leukemia, 12% with lymphoma, and 5% with solid tumors.…”

Section: Nih Public Accessmentioning

confidence: 99%

“…In addition, invasive aspergillosis (IA) surpassed invasive candidiasis (IC) as the most common IFI encountered in the HSCT population: Aspergillus accounted for 43% of infections and Candida accounted for 28%, followed by There are no recent, multicenter studies describing the incidence and clinical outcome of IFIs among the general oncology population and it is difficult to obtain an accurate estimate of the frequency of fungal infections in this population from the published literature as most reports do not provide sufficient information regarding the patients' underlying disease. In general, compared with patients with solid tumors, patients with hematologic malignancies are at increased risk for fungal disease and response to IFI treatment is lower [10]. A 1992 international autopsy survey of patients with cancer identified fungal infections in 25% of patients with leukemia, 12% with lymphoma, and 5% with solid tumors.…”

Section: Epidemiology Of Invasive Fungal Infectionsmentioning

confidence: 99%

Fungal Infections in Transplant and Oncology Patients

Person

Kontoyiannis

Alexander

2011

Hematology/Oncology Clinics of North America

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“…Previous studies showed that invasive candidiasis is a common and serious complication of cancer and its therapy (5). In cancer patients, it has been hypothesized that it develops from initial gI colonization with subsequent translocation into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

A comparative histopathological study of systemic candidiasis in association with experimentally induced breast cancer

Choo

Chakravarthi²,

Wong³

et al. 2010

Oncology Letters

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Abstract. systemic candidiasis is a fungal infection which coupled with solid malignancies places patients at high risk of succumbing to the disease. Few studies have shown evidence of the relationship between systemic candidiasis and malignancy-induced immunosuppression disease especially in breast cancer. At present, animal studies that exclusively demonstrate this relationship have yet to be conducted. the exact causative mechanism of systemic candidiasis is currently under much speculation. this study therefore aimed to demonstrate this relationship by observing the histopathological changes of organs harvested from female Balb/c mice which were experimentally induced with breast cancer and inoculated with systemic candidiasis. the mice were randomly assigned to five different groups (n=12). The first group (group 1) was injected with phosphate buffer solution, the second (group 2) with systemic candidiasis, the third (group 3) with breast cancer and the final two groups (groups 4 and 5) had both candidiasis and breast cancer at two different doses of candidiasis, respectively. Inoculation of mice with systemic candidiasis was performed by an intravenous injection of Candida albicans via the tail vein following successful culture methods. Induction of mice with breast cancer occurred via injection of 4T1 cancer cells at the right axillary mammary fatpad after effective culture methods. the prepared slides with organ tissues were stained with hematoxylin and eosin, periodic acidic schiff and gomori methenamine silver stains for a histopathological analysis. grading of primary tumour and identification of metastatic deposits, as well as scoring of inflammation and congestion in all the respective organs was conducted. statistical tests performed to compare groups 2 and 4 showed that group 4 exhibited a highly statistically significant increase in organ inflammation and congestion (p<0.01). The median severity of candidiasis in the kidneys and liver also increased in group 4 as compared to group 2. In conclusion, based on the above evidence, systemic candidiasis significantly increased in mice with breast cancer.

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Invasive candidiasis in cancer patients: observations from a randomized clinical trial

Cited by 46 publications

References 35 publications

Oral <i>Candidiasis</i> amongst cancer patients at Qods Hospital

Oral <i>Candidiasis</i> amongst cancer patients at Qods Hospital

Fungal Infections in Transplant and Oncology Patients

A comparative histopathological study of systemic candidiasis in association with experimentally induced breast cancer

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