Invasive Candidiasis: Epidemiology and Risk Factors

Cortés, Jorge Alberto; Corrales, Ivohne Fernanda

doi:10.5772/intechopen.81813

Cited by 11 publications

(10 citation statements)

References 138 publications

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“…The disease itself and the therapy used often lead to immunosuppression and disruption of the mechanisms of both humoral and cellular immune response [ 4 ]. The incidence of candidiasis among cancer patients treated in hospitals is higher compared to patients hospitalized for other causes [ 6 ].…”

Section: Overview Of Candida Sppmentioning

confidence: 99%

Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis

Czechowicz¹,

Nowicka²,

Gościniak³

2022

IJMS

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Vulvovaginal candidiasis (VVC) is one of the most common types of vaginal infections in women around the world and is often underestimated by both patients and doctors. Research on the pathogenesis of fungal vaginal infections over the last 20 years has resulted in a closer understanding of the virulence factors involved in Candida epithelial invasion and their mechanisms of action. Recently, attention was drawn to the enormous complexity of the interaction between yeast-like fungi and host cells, as well as the level of complexity of the host’s response to infection and their impact on the course and treatment of VVC. Our work provides a broad description of already known and some new reports on Candida virulence factors (such as phenotypic switching or biofilm formation capacity) and their importance for tissue invasion in VVC. At the same time, we also focus on interactions with host cells and local innate immune mechanisms involved in the response to vaginal fungal invasion that are now considered equally important in this case. The presented review describes the most important aspects of the still unknown pathogenicity of Candida associated with vaginal infections.

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Section: Overview Of Candida Sppmentioning

confidence: 99%

Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis

Czechowicz¹,

Nowicka²,

Gościniak³

2022

IJMS

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“…A concentração inibitória mínima foi considerada a menor concentração capaz de inibir o crescimento visível do microrganismo [37]. O inóculo para cada um dos microrganismos foi preparado de acordo com o tubo 0,5 da escala de McFarland onde contém aproximadamente 1-5x10 6 UFC (unidades formadoras de colônia/mL). Os experimentos foram conduzidos com aproximadamente 1-5 x 10 5 UFC/mL em cada cavidade.…”

Section: Avaliação Da Atividade Antifúngicaunclassified

“…Dentre as espécies de Candida spp., a Candida albicans é a mais prevalente tanto em pacientes sadios quanto em indivíduos mórbidos [5], em que, apenas em 2015 acometeu entre 9,5 a 14,4 indivíduos para cada 100.000 habitantes norte-americanos [6].…”

Section: Introductionunclassified

Síntese, atividade antifúngica e docking molecular de derivados do eugenol

et al. 2020

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Este trabalho descreve a síntese e atividade antifúngica de derivados do eugenol e o docking molecular do eugenol contendo uma unidade 1,2,3-triazólica. Os derivados de eugenol foram obtidos por modificações fenólicas na hidroxila, enquanto a concentração inibitória mínima foi determinada pelo método de microdiluição em caldo. O docking molecular do derivado de eugenol com funcionalidade 1,2,3-triazol foi realizado com a enzima esterol 14-alfa desmetilase (CYP51) e demonstrou que este composto não interage favoravelmente com esta enzima, diferentemente do posaconazol. Os derivados do eugenol foram obtidos com bons rendimentos e a avaliação antifúngica mostrou que, após modificações, a atividade antifúngica foi mantida em alguns exemplos. O resultado do docking molecular nos permitiu vislumbrar alguns motivos que justificam a ausência de atividade antifúngica do derivado de eugenol com funcionalidade 1,2,3-triazol. Em resumo, o artigo fornece informações importantes que ajudarão na realização de pesquisas futuras envolvendo este produto natural.

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“…Invasive candidiasis is a particularly lifethreatening infection, whose increased prevalence is closely associated with epidemic HIV infection, emergence of malignancies, solid organ transplantation and diabetes. 18,19 Out of more than 20 different Candida species known to cause human infections, C. albicans is the most prevalent pathogen, causing superficial, mucosal, deep-seated and systemic infections. 20 Moreover, invasive candidasis caused by C. albicans represents the fourth leading cause of all bloodstream infections worldwide, with the global burden of approximately 750.000 cases annually and disturbingly high mortality rate of 40-75%, surpassing thus many bacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Sovari

Radakovic

Roch

et al. 2021

Preprint

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Antimicrobial resistance (AMR) is a major emerging threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. While the problem escalates, lack of financial incentive has lead major pharmaceutical companies to interrupt their antibiotic drug discovery programs. The World Health Organisation (WHO) has called for novel solutions outside the traditional development pathway, with emphasis on new classes of active compounds with nonclassical mechanisms of action. Metal complexes are an untapped source of antibiotic potential owing to unique modes of action and a wider range of three-dimensional geometries as compared to purely organic compounds. In this study, we present the antimicrobial and antifungal efficacy of a family of rhenium tricarbonyl diimine complexes with varying ligands, charge and lipophilicity. Our study allowed the identification of potent and non-toxic complexes active in vivo against S. aureus infections at MIC doses as low as 300 ng/mL, as well as against C. albicans-MRSA mixed co-infection. The compounds are capable of suppressing the C. albicans morphogenetic yeast-to-hyphal transition, eradicating fungal-S. aureus co-infection, while showing no sign of cardio-, hepato-, hematotoxiciy or teratogenicity.The following ALERTS were generated. Each ALERT has the format test-name_ALERT_alert-type_alert-level. Click on the hyperlinks for more details of the test.

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Invasive Candidiasis: Epidemiology and Risk Factors

Cited by 11 publications

References 138 publications

Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis

Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis

Síntese, atividade antifúngica e docking molecular de derivados do eugenol

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

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