2011
DOI: 10.3324/haematol.2011.044636
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Invasive aspergillosis in patients with hematologic malignancies: incidence and description of 127 cases enrolled in a single institution prospective survey from 2004 to 2009

Abstract: BackgroundThe study objectives were: 1) to report on invasive aspergillosis patients in a hematology department; and 2) to estimate its incidence according to the hematologic diagnosis. Design and MethodsA prospective survey of invasive aspergillosis cases was undertaken between January 2004 and December 2009 in the hematology department of a university hospital. Meetings with clinicians, mycologists and infection control practitioners were organized monthly to confirm suspected aspergillosis cases. Demographi… Show more

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Cited by 67 publications
(52 citation statements)
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“…In high-risk patients, the mortality rate of aspergillosis disease is reported to reach as high as 80% (Nicolle et al, 2011). However, conventional treatment in this setting is unsatisfactory, eg., itraconazole is low in its bioavailability and further could induce drug resistance, amphotericin B is associated with severe adverse reactions (Miller et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…In high-risk patients, the mortality rate of aspergillosis disease is reported to reach as high as 80% (Nicolle et al, 2011). However, conventional treatment in this setting is unsatisfactory, eg., itraconazole is low in its bioavailability and further could induce drug resistance, amphotericin B is associated with severe adverse reactions (Miller et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…3 The lacrimal gland not only protects the ocular surface via a tear film, but also supplies the ocular surface with protective immu- (1.3%). 10 In comparison, the incidence of invasive aspergillosis among patients with NHL was 0.8% in one series. 11 While once not considered an at risk population, the incidence of invasive aspergillosis among those with aggressive NHL and multiple myeloma has increased over time due to the use of intensive chemotherapy.…”
Section: Discussionmentioning
confidence: 88%
“…1 The incidence of invasive aspergillosis in patients with hematologic malignancies has been reported to be as high as 3.1%, with A. fumigatus representing the most commonly isolated species. 10,11 The incidence of invasive aspergillosis is highest among patients with acute myeloid leukemia (1.9%), followed by those with acute lymphoblastic leukemia …”
Section: Introductionmentioning
confidence: 99%
“…The probability of invasive aspergillosis infection (IF) in patients with hematologic malignancies is 3.1 %, and the 90-day mortality rate is as high as 42 % [1]. Prognoses mainly depend on the state of the disease and the duration of neutropenia.…”
Section: Introductionmentioning
confidence: 99%