Invasive Apophysomyces variabilis Infection in a Burn Patient

Cruz, Wilfred P. dela; Calvano, Tatjana; Griffith, Matthew E.; White, Christopher E.; Kim, Seung H.; Sutton, Deanna A.; Thompson, Elizabeth H.; Fu, Jianmin; Wickes, Brian L.; Guarro, Josep; Hospenthal, Duane R.

doi:10.1128/jcm.00671-12

Cited by 19 publications

(24 citation statements)

References 17 publications

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“…A case of A. variabilis invasive wound infection after burn injury has been reported recently in Japan. 5 Important attention is drawn to the 13 cases of necrotizing soft tissue infections caused by A. trapeziformis following a F5 tornado that swept through Joplin (Missouri, USA) in May 2011, 7,13,18 and an additional case reported 10 months after the tornado. 6 This seems to demonstrate the hypothesis of Alvarez et al that diverse clades of Apophysomyces are prevalent in different parts of the world, i.e.…”

Section: Discussionmentioning

confidence: 99%

Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Chander

Stchigel

Alastruey‐Izquierdo

et al. 2015

Revista Iberoamericana de Micología

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Section: Discussionmentioning

confidence: 99%

Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Chander

Stchigel

Alastruey‐Izquierdo

et al. 2015

Revista Iberoamericana de Micología

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“…There are few cases of A. variabilis infection reported in the literature, mostly form India [7] , [8] , [9] , [10] , [11] , [13] , [15] , [16] ( Table 1 ). The number of cases is likely to be underestimated because A. variabilis does not produce spores readily in traditional mycological culture media used in clinical laboratories, has special nutritional requirements, grows at high temperatures (37–42 °C) and after prolonged periods of incubation (7–10 days) [9] .…”

Section: Discussionmentioning

confidence: 99%

“… ND DN ND [9] 1 21 Skin Dorsal Burn 90% TBS Without. Death [10] 5 29–45 Skin 1 Thoracic wall. 2 Trauma.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient

Rodríguez

Morales-López

Rodríguez

et al. 2018

Medical Mycology Case Reports

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Mucormycosis caused by Apophysomyces variabilis is rarely reported in humans. A case of A. variabilis infection in an immunocompetent men after friction burns in a car accident is described. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required extensive surgical debridement and total colonic defunctioning colostomy associated with prolonged antifungal therapy. A. variabilis infection should be considered as a differential diagnosis of rapidly progressive necrotizing skin and soft tissue infections in immunocompetent individuals.

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“…Notably, outbreaks of infection have followed natural disasters, well illustrated by the cluster of Apophysomyces trapeziformis softtissue infections following a tornado in Joplin, USA (see Outbreaks section). Infection caused by more uncommon Apophysomyces species include eight case reports of Apophysomyces variabilis infections, all of necrotizing soft-tissue infection [19,20], and one case of a novel species Apophysomyces mexicanus with soft-tissue infection following traumatic inoculation [21].…”

Section: Apophysomyces and Saksenaea Speciesmentioning

confidence: 99%

Emerging infections caused by non- Aspergillus filamentous fungi

Douglas

Chen

Slavin

2016

Clinical Microbiology and Infection

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There are three broad groups of non-Aspergillus moulds: the mucormycetes, the hyalohyphomycetes and the phaeohyphomycetes. Infections with these pathogens are increasingly reported, particularly in the context of increasing use of immunosuppressant agents and improved diagnostics. The epidemiology of non-Aspergillus mould infections varies with geography, climate and level of immunosuppression. Skin and soft-tissue infections are the predominant presentation in the immunocompetent host and pulmonary and other invasive infections in the immunocompromised host. The more common non-Aspergillus moulds include Rhizopus, Mucor, Fusarium and Scedosporium species; however, other emerging pathogens are Rasamsonia and Verruconis species, which are discussed in this article. Outbreaks of non-Aspergillus mould infections have been increasingly reported, with contaminated medical supplies and natural disasters as common sources. Currently culture and other conventional diagnostic methods are the cornerstone of diagnosis. Molecular methods to directly detect and identify mould pathogens in tissue and body fluids are increasingly used.

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Invasive Apophysomyces variabilis Infection in a Burn Patient

Abstract: e Apophysomyces variabilis is an emerging fungal pathogen that can cause significant infections in immunocompetent patients. We report a case of A. variabilis invasive wound infection in a 21-year-old male after a self-inflicted burn injury. CASE REPORT

Cited by 19 publications

References 17 publications

Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient

Emerging infections caused by non- Aspergillus filamentous fungi

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