Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Chander, Jagdish; Stchigel, Alberto M.; Alastruey‐Izquierdo, Ana; Jayant, Mayank; Bala, Kiran; Rani, Hena; Handa, Uma; Punia, Rajpal Singh; Dalal, Usha; Attri, Ashok Kumar; Monzón, Araceli; Cano-Lira, José F.; Guarro, Josep

doi:10.1016/j.riam.2014.06.005

Cited by 47 publications

(56 citation statements)

References 15 publications

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“…Tuberculid and suppurative granulomatous patterns have also been reported. Unlike SCM cases, hyphae are scarce in PCM cases, particularly on immunocompetent [14,21,65,74].…”

Section: Diagnosismentioning

confidence: 95%

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Bonifáz

Tirado‐Sánchez

Calderón

et al. 2015

Curr Fungal Infect Rep

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Cutaneous mucormycosis (CM) is caused by ubiquitous filamentous fungi belonging to the order Mucorales. It is a rare, emerging mycosis, with increasing incidence since the last two decades, only surpassed by rhinocerebral and pulmonary mucormycosis. CM can be further classified in primary and secondary clinical forms. Primary cases can be seen on immunocompetent patients, frequently due to traumatic injuries, while in immunocompromised patients (those with diabetes mellitus or hematologic malignancies), lesions can arise at catheter insertion sites or after the use of contaminated adhesive tapes. Clinical features of primary cutaneous mucormycosis (PCM) are necrosis, followed by ulceration, generally associated to good prognosis. Secondary cutaneous mucormycosis (SCM) is related to rhinocerebral and/or disseminated forms. SCM usually starts as a palpebral fistula, as an erythematous area that rapidly evolves to necrosis and ulceration, related to worse prognosis. Direct examination, cultures, skin biopsies, and molecular tests are performed to diagnose both clinical forms. Liposomal amphotericin B (LAmB) in combination with surgical debridement constitutes the treatment of choice; however, for SCM, the addition of posaconazole or caspofungin is recommended.

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“…Tuberculid and suppurative granulomatous patterns have also been reported. Unlike SCM cases, hyphae are scarce in PCM cases, particularly on immunocompetent [14,21,65,74].…”

Section: Diagnosismentioning

confidence: 95%

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Bonifáz

Tirado‐Sánchez

Calderón

et al. 2015

Curr Fungal Infect Rep

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“…[5]. In our experience, Apophysomyces variabilis is the commonest agent causing primary cutaneous infections in northern India, with uncontrolled diabetes and diabetic ketoacidosis as the most common predisposing factor [7].…”

Section: Discussionmentioning

confidence: 92%

Changing Epidemiology of Mucoralean Fungi: Chronic Cutaneous Infection Caused by Mucor irregularis

et al. 2015

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“…Mucorales illustrate perfectly the notion of hostpathogen adaptation: they emerged a few decades ago in haematological populations and their growing evolution follows that of the patients at risk. Among Mucorales, epidemiological microphenomena are noteworthy as illustrated by breakthrough of rare species, as for example the genera Apophysomyces, that have emerged in unusual scenarios, such as those observed in natural disasters or as primary cutaneous infections reported in China (Li et al, 2013;Strasfeld et al, 2013;Tribble et al, 2013;Chander et al, 2014).…”

Section: Mucorales: An Expanding Aggressive Bugmentioning

confidence: 99%

Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

Debourgogne

Dorin

Machouart

2016

Environ Microbiol Rep

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Over the last few decades, the number of patients susceptible to invasive filamentous fungal infections has steadily increased, especially in populations suffering from hematological diseases. The pathogens responsible for such mycoses are now quite well characterized, such as Aspergillus spp. - the most commonly isolated mold -, Mucorales, Fusarium spp., Scedosporium spp. or melanized fungi. An increase in the incidence of this category of 'emerging' fungi has been recently highlighted, evoking a shift in fungal ecology. Starting from these medical findings, taking a step back and adopt a wider perspective offers possible explanations of this phenomenon on an even larger scale than previously reported. In this review, we illustrate the link between emerging fungi in medicine and changes in ecology or human behaviours, and we encourage integrative approaches to apprehend the adverse effects of progress and develop preventive measures in vast domains, such as agriculture or medicine.

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Fungal necrotizing fasciitis, an emerging infectious disease caused by Apophysomyces (Mucorales)

Cited by 47 publications

References 15 publications

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Changing Epidemiology of Mucoralean Fungi: Chronic Cutaneous Infection Caused by Mucor irregularis

Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

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