Invasive and in situ lesions of squamous cell carcinoma are independent factors for postoperative surgical‐site infection after outpatient skin tumors surgery: A retrospective study of 512 patients

Abstract

Surgical-site infection (SSI) is one of the major postoperative complications in surgery. Although the rate of SSI in dermatological surgery is regarded as low, it may cause significant morbidity such as ruptured suture or skin necrosis. 1 Dermatological surgeries for skin tumors involve various tumor types, surgical methods, and surgical sites, and these factors differ in each case. However, factors associated with SSI in dermatological surgery are not fully elucidated.Moreover, there are currently no standards for perioperative antibiotic use in dermatological surgery for skin tumors. Therefore, we retrospectively investigated 512 patients who underwent outpatient surgery for skin tumors to analyze factors associated with postoperative SSI.

Are Specific Body Sites Prone for Wound Infection After Skin Surgery? A Systematic Review and Meta-Analysis

“…Meta-analysis of 4 studies showed a tendency toward a higher risk for SSI below the knee. 11–14 The finding was not significant, and heterogeneity was substantial (RR 2.81, CI 0.91–8.68, I 2 = 86%, see Supplemental Digital Content , Figure S9, http://links.lww.com/DSS/B4). In line with the analysis of the lower extremity, this may be due to differences in the surgical setting: By contrast to the remaining studies, the only study which showed no risk difference included hospitalized patients.…”

“…Meta-analysis of 7 studies showed no risk difference for SSI on the upper extremity (RR 1.66 CI 0.63-4.37, I 2 5 75%, see Supplemental Digital Content, Figure S9, http:// links.lww.com/DSS/B4). 7,[11][12][13][17][18][19] Heterogeneity among the studies was substantial, and the direction of the effect varied. Five studies were retrospective and 2 prospective.…”

“…Meta-analysis of 9 trials yielded significantly lower wound infection rates on the trunk (RR 0.75, CI 0.58–0.96, I 2 = 0%, Figure 2). 6,7,12,13,15,17–20 Heterogeneity was not important. The results were based on 4 studies of good, 2 of fair, and 3 of poor quality.…”

“…Meta-analysis of 7 studies demonstrated significantly higher SSI rates on the lips (RR 1.90, CI 1.13-3.19, I 2 5 0%, Figure 1). 11,13,15,17,19,20,22 Heterogeneity was not important. Four studies showed good quality, 1 fair quality, and 2 poor quality.…”

“…7 Meta-analysis of 9 trials showed a significantly higher risk for SSI on the lower extremity compared with other locations (RR 2.42, CI 1.43-4.07, I 2 5 71%, Figure 3). 7,[11][12][13][14][17][18][19]22 Heterogeneity among the studies was substantial. All studies that were conducted in the outpatient setting showed significantly higher infection rates.…”