Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients

He, Siyu; Xiong, Qinmei; Tian, Chong; Li, Li; Zhao, Jing; Lin, Xuechun; Guo, Xing Peng; He, Yuqin; Liang, Wangqun; Zuo, Xuezhi; Ying, Chenjiang

doi:10.1007/s00394-021-02669-y

Cited by 19 publications

(13 citation statements)

References 48 publications

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“…Burdock ITFs have been shown reduce postprandial blood GLU and TC levels, endowing hypoglycemic and hypolipidemic activities as the result of the SCFAs [ 5 , 27 , 36 , 40 ]. The results presented here suggest that burdock ITFs could reduce serum UA levels in mice originating from UA degradation by the intestinal microbiota [ 15 ]. Burdock ITFs may have a protective effect on renal function and lower the risk of renal disease, although further studies are needed to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Effects of burdock inulin-type fructans exposure on the physiological function of healthy mice and their filial generation

LIU¹,

Yuan²,

Wang

et al. 2023

J. Vet. Med. Sci.

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Inulin-type fructans (ITFs) have been shown to possess various biological activities. However, studies on their safety and side effects are limited. Hence, we aimed to evaluate the possible effects of burdock ITFs on the physiological indices of healthy mice and their filial generation when fed for six months. Thirty-two C57BL/6J mice were randomly divided into two groups; a normal control (NC) and an ITFs group. The parental generations were kept in one cage with free access to a normal diet and double-distilled water (P-NC group) or burdock ITFs drinking water (P-ITFs group, 2% w/v). The filial generations (F-NC group and F-ITFs group) were kept separately and were fed as their parental generation. Behavior, organ/body weight, serum indices, histopathology, time of production, and number of pup births were observed. There were no significant adverse effects on these indices.Functional indices of the spleen, lung, heart, and pancreas of the ITFs groups were higher than those of the NC groups, respectively. Interestingly, the serum glucose (GLU), total cholesterol (TC), uric acid (UA) and creatine kinase (CK) levels of the ITFs groups were lower than those of the NC groups.Meanwhile, the pregnancy number and pup birth number of the P-ITFs group were more than those of P-NC group. Therefore, long-term consumption of burdock ITFs has no obvious adverse effects on the health of parental mice and their offspring, but may contribute to reproductive capacity, fatigue reduction, and risk reduction of renal disease.

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Section: Discussionmentioning

confidence: 99%

Effects of burdock inulin-type fructans exposure on the physiological function of healthy mice and their filial generation

LIU¹,

Yuan²,

Wang

et al. 2023

J. Vet. Med. Sci.

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“…Medical information was obtained from the electronic medical records, including the use of 1.5% and 2.5% glucose dialysate, daily ultrafiltration volume, dialysis efficiency (Kt/V), residual renal function, and the calculated formula, which was described in our previous study. [ 33 ]…”

Section: Methodsmentioning

confidence: 99%

The Effect of Inulin‐Type Fructans on Plasma Trimethylamine N‐Oxide Levels in Peritoneal Dialysis Patients: A Randomized Crossover Trial

Xiong

Xiao

et al. 2023

Molecular Nutrition Food Res

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Scope: Trimethylamine N-oxide (TMAO), an important proatherogenic uremic toxin, is oxidized by hepatic-flavin monooxygenases from gut microbiome-generated trimethylamine (TMA). The present study aims to explore whether manipulating the gut microbiota by inulin-type fructans (ITFs) can reduce circulating TMAO levels in peritoneal dialysis patients. Methods and results: This is a randomized, double-blind, placebo-controlled, crossover trial with 10 g day −1 ITFs intervention for 3 months in continuous ambulatory peritoneal dialysis patients. The gut microbiome is measured, and TMA-producing gene clusters are annotated using shotgun metagenomic sequencing. Fecal and plasma TMA, plasma TMAO, and daily urine excretion and dialysis removal of TMAO are measured. Finally, 22 participants complete the trial. The daily intake of macronutrients and TMAO precursors is comparable during the prebiotics, washout, and placebo interventions. The ITFs intervention increases the Firmicutes/Bacteroidetes (F/B) ratio (p = 0.049) of gut microbiome. However, no significant influences are observed on fecal TMA content, circulating TMAO levels, or TMA-producing gene clusters, including choline TMA-lyase (CutC/D), carnitine monooxygenase (CntA/B), and betaine reductase (GrdH). Conclusions: Intervention with 10 g day −1 of ITFs for 3 months is not sufficient to reduce plasma TMAO levels in peritoneal dialysis patients, but it improves the gut microbiome composition.

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“…Inulin is being investigated as a potential modulator of the gut microbiota with benefits for human health. The most notable recently reported changes induced by inulin are an increase in Bifidobacterium, an improvement in function, as well as benefits in host metabolism for a variety of metabolic diseases, including obesity, type 2 diabetes, kidney disease, intestinal disease, and non-alcoholic fatty liver disease [ 97 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ].…”

Section: Human Studies Examining Polysaccharide Modulation Of Gut Mic...mentioning

confidence: 99%

Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health

Álvarez‐Mercado

Plaza‐Díaz

2022

Nutrients

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A polysaccharide is a macromolecule composed of more than ten monosaccharides with a wide distribution and high structural diversity and complexity in nature. Certain polysaccharides are immunomodulators and play key roles in the regulation of immune responses during the progression of some diseases. In addition to stimulating the growth of certain intestinal bacteria, polysaccharides may also promote health benefits by modulating the gut microbiota. In the last years, studies about the triad gut microbiota–polysaccharides–health have increased exponentially. In consequence, in the present review, we aim to summarize recent knowledge about the function of dietary polysaccharides on gut microbiota composition and how these effects affect host health.

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Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients

Cited by 19 publications

References 48 publications

Effects of burdock inulin-type fructans exposure on the physiological function of healthy mice and their filial generation

Effects of burdock inulin-type fructans exposure on the physiological function of healthy mice and their filial generation

The Effect of Inulin‐Type Fructans on Plasma Trimethylamine N‐Oxide Levels in Peritoneal Dialysis Patients: A Randomized Crossover Trial

Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health

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