Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models

Zou, Jun; Reddivari, Lavanya; Shi, Zhenda; Li, Shiyu; Wang, Yanling; Bretin, Alexis; Ngo, Vu L.; Flythe, Michael D.; Pellizzon, Michael; Chassaing, Benoît; Gewirtz, Andrew T.

doi:10.1016/j.jcmgh.2021.04.014

Cited by 39 publications

(28 citation statements)

References 52 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For double staining of insulin and glucagon, the procedure was performed as described with minor modifications. 34 Briefly, the pancreatic sections were dewaxed, rehydrated, soaked in ethylenediaminetetraacetic acid buffer, and heated in a microwave oven for antigen retrieval. The sections were then blocked with bovine serum albumin before incubation with the corresponding primary antibodies, a secondary detection antibody, and DAPI dye solution.…”

Section: Methodsmentioning

confidence: 99%

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Liu

Huang

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Liu

Huang

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Although most studies showed that SCFAs exerted health benefits, several studies found that some SCFAs could be useless or exhibit side effects in some conditions. Although SCFAs from inulin fermentation had potential to prevent or treat type 1 diabetes, direct SCFAs oral administration alone did not provide a significant impact on the diabetes, which might be attributed to oral administration did not allow for enough SCFAs to reach the site of action (cecum and colon) [ 116 ]. Moreover, a meta-analysis including 44 randomized controlled trial studies found that acetate, propionate, butyrate, and the mixed SCFAs had no effect on insulin and blood glucose in humans [ 120 ].…”

Section: The Side Effects Of Scfasmentioning

confidence: 99%

Health Benefits and Side Effects of Short-Chain Fatty Acids

Xiong

Zhou

et al. 2022

Foods

View full text Add to dashboard Cite

The gut microbiota and their metabolites could play an important role in health and diseases of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome fermentation of dietary fiber and could also be produced by bacteria of the skin and vagina. Acetate, propionate, and butyrate are three major SCFAs, and their bioactivities have been widely studied. The SCFAs have many health benefits, such as anti-inflammatory, immunoregulatory, anti-obesity, anti-diabetes, anticancer, cardiovascular protective, hepatoprotective, and neuroprotective activities. This paper summarizes health benefits and side effects of SCFAs with a special attention paid to the mechanisms of action. This paper provides better support for people eating dietary fiber as well as ways for dietary fiber to be developed into functional food to prevent diseases.

show abstract

“…The effect was associated with reduced Th1 skewing and increased Treg frequency in the mLN and the lamina propria of the small intestine. Besides replenishing protective microbes through probiotic supplementation, the prebiotic approach aims at enhancing SCFA generation through increased consumption of dietary fiber such as inulin ( 187 ). Increased dietary fiber fermentation by intestinal microbes can then increase the SCFA output in the gut.…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Host-microbiota interactions shaping T-cell response and tolerance in type 1 diabetes

2022

View full text Add to dashboard Cite

Type-1 Diabetes (T1D) is a complex polygenic autoimmune disorder involving T-cell driven beta-cell destruction leading to hyperglycemia. There is no cure for T1D and patients rely on exogenous insulin administration for disease management. T1D is associated with specific disease susceptible alleles. However, the predisposition to disease development is not solely predicted by them. This is best exemplified by the observation that a monozygotic twin has just a 35% chance of developing T1D after their twin’s diagnosis. This makes a strong case for environmental triggers playing an important role in T1D incidence. Multiple studies indicate that commensal gut microbiota and environmental factors that alter their composition might exacerbate or protect against T1D onset. In this review, we discuss recent literature highlighting microbial species associated with T1D. We explore mechanistic studies which propose how some of these microbial species can modulate adaptive immune responses in T1D, with an emphasis on T-cell responses. We cover topics ranging from gut-thymus and gut-pancreas communication, microbial regulation of peripheral tolerance, to molecular mimicry of islet antigens by microbial peptides. In light of the accumulating evidence on commensal influences in neonatal thymocyte development, we also speculate on the link between molecular mimicry and thymic selection in the context of T1D pathogenesis. Finally, we explore how these observations could inform future therapeutic approaches in this disease.

show abstract

Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models

Abstract: Gut microbiota play an important role in the development of type 1 diabetes. We show herein that fermentable fiber inulin modulates gut microbiota to prevent and treat STZinduced diabetes and to delay diabetes development in non-obese diabetes (NOD) mouse models.

Cited by 39 publications

References 52 publications

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Health Benefits and Side Effects of Short-Chain Fatty Acids

Host-microbiota interactions shaping T-cell response and tolerance in type 1 diabetes

Contact Info

Product

Resources

About