Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation

Anti-inflammatory Terpenes from Flowers of Inula japonica

“…The 13 C NMR and DEPT spectra of compound 1 showed 18 carbons for the sesquiterpene, with an acetoxy group and methoxy groups Abstract ! Five new terpenes (1-5) and ten known compounds (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were isolated from Inula japonica, and their structures were identified by spectroscopic analysis. Compounds 3 and 14 showed positive inhibitory effects on nitric oxide production.…”

“…Pharmacological studies have demonstrated the diverse effects of these flowers, including their antidiabetes, hypolipidemia, antifungal, antibacterial, antitumor, antihepatitis, and hepatoprotective properties [2][3][4][5][6]. We previously demonstrated the anti-inflammatory activities of the flower extracts from I. japonica, such as the attenuation of nitric oxide (NO) production and inflammatory cytokine expression in macrophages [7], suppression of eicosanoid generation and degranulation in mast cells [8], and inhibition of inflammatory cell infiltration and mucus hypersecretion in a murine model of asthma [9]. Chronic or acute inflammation is a multiple process mediated by the activation of inflammatory or immune cells [10].…”

IVSE, isolated from Inula japonica,suppresses LPS-induced NO production via NF-κB and MAPK inactivation in RAW264.7 cells

“…I. japonica has been used in traditional Chinese medicine for the treatment of cough, digestive disorders, and bronchitis [6]. We previously reported the inhibition of allergic reaction [20], attenuation of inflammatory response [4], and anti-asthmatic effect on murine model of asthma [26], by the flower extracts of I. japonica. Besides inflammation and allergic diseases, diabetes, cancer and cardiovascular diseases are also closely related to inflammation [8,35,36].…”

“…(I. japonica) has been used in traditional Chinese medicine for the treatment of digestive and bronchitis inflammation [28]. In our previous studies, we demonstrated that flower extract of I. japonica showed anti-inflammatory and anti-asthmatic activities in vivo and in vitro [4,20,26]. We also isolated several compounds from I. japonica and determined their anti-inflammatory activities [33].…”

In vitro and in vivo anti-allergic effects of an extract of a traditional Chinese medicine preparation

“…We examined the anti-allergic effects of AEF using a rat PCA model. Local extravasation was induced by a local injection of anti-DNP IgE, followed by an antigenic challenge (Lu et al 2012). PCA was best visualized by the extravasation of dye.…”