Intussusception secondary to signet ring cell adenocarcinoma in adolescent

Thibodeau, Ryan; Jafroodifar, Abtin; Bakrukov, Dmitriy; Alkukhun, Leen; Mirchia, Kavya; Majmudar, Anand; Gupta, Sandeep; Hanumaiah, Ravikumar

doi:10.1016/j.radcr.2021.02.027

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…[ 17 ] Thibodeau et al reported that a 15-year-old boy was admitted with abdominal pain and diagnosed with ascending and successfully treated colon SRCC with colectomy. [ 18 ] The patient had been alive for 6 months. Recently, Mahajan et al published a report on seven cases of CRC, two of which were signet-ring cell adenocarcinoma and were located in the right and left colon, respectively; both of these patients died.…”

Section: Discussionmentioning

confidence: 99%

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A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

Erginel

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Signet-ring cell adenocarcinoma of the colon is well-recognized in adult patients who are extremely rare and not well-documented in children. Our study aims to raise awareness about this rare disease and its long-term outcomes. METHODS: We retrospectively evaluated patients with signet-ring cell colon adenocarcinoma. RESULTS: Six patients, three boys and three girls, with a mean age of 14.83 (range, 13–17 years), presented with signs of intestinal obstruction and were diagnosed with signet-ring cell colon adenocarcinoma. All patients had air-fluid levels on abdominal X-ray. Abdominal ultrasonography of all patients revealed subileus. Abdominal computed tomography was performed in five patients, and pre-operative colonoscopy was conducted in two patients before the emergency intervention. All of the patients underwent emergent exploratory laparotomy with the preliminary diagnosis of acute abdomen. In two patients, debulking surgery followed by a stoma was performed. The remaining four patients were treated with anastomosis following intestinal resection. All girls had metastases on the ovary. One of the patients died due to the burden of multiple metastases in the early period, and three died in the sixth post-operative year. We have been following the remaining two patients since then. CONCLUSION: Although signet-ring cell carcinomas (SRCCs) are rare, they should be considered in the differential diagnosis of acute abdomen and intestinal obstruction in pediatric patients. Despite early diagnosis and treatment, SRCC has a poor prognosis in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

“…All pediatric patients detected in the past 20 years are presented in Table 2. [4,5,[13][14][15][16][17][18][19] Even the most extensive series consisted of only four cases. [16] In 2017, Li et al provided a case report and reviewed all the literature in this area.…”

Section: Discussionmentioning

confidence: 99%

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

Erginel

2023

Ulus Travma Acil Cerrahi Derg

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“…Intussusception is an unusual clinical presentation of this tumour. In the published literature, we were only able to find three cases, all of which occurred in adult patients < 50 years [ 8 – 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception

Gaskin

Reid

O’Shea

et al. 2022

Case Reports in Pathology

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“…In general, most intussusceptions can be categorized as primary or idiopathic, with thickened bowel wall lymphoid tissue (Peyer patches) acting as the lead point. Approximately 5–12% of intussusceptions are pathological, which usually present with different symptoms and are caused by conditions such as Meckel’s diverticula ( 4 ), intestinal polyps ( 5 , 6 ), intestinal duplication ( 7 ), allergic purpura ( 8 ) and some rare digestive tract malignant tumors ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nomogram for Predicting Pathological Intussusceptions in Children Prior to Surgical Intervention

Duan

Liu

et al. 2022

Front. Pediatr.

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PurposeEstablish and validate a nomogram to help predict the preoperative risk of a pathological intussusception.MethodsA primary cohort of patients who underwent surgery for an intussusception were enrolled from one center, while a validation cohort consisted of patients from another center. Multivariate logistic regression analysis was used to identify the variables to build the nomogram. A calibration curve accompanied by the Hosmer-Lemeshow test was used to assess the calibration of the nomogram. To quantify the discrimination of the nomogram, Harrell’s C-index was calculated. The performance of the validated nomogram was tested in the external validation cohort. The logistic regression formulae created during the analysis of the primary cohort was applied to all patients in the external validation cohort, and the total points for each patient were calculated.ResultsThe primary cohort consisted of 368 patients and the validation cohort included 74. The LASSO logistic algorithm identified three (recurrence episodes, mass size, and infection history) out of 11 potential clinical variables as significantly predictive of a pathologic intussusception. The C-index for the predictive nomogram was 0.922 (95% CI, 0.885–0.959) for the primary cohort and 0.886 (95% CI, 0.809–0.962) for the validation cohort. The decision curve showed that if the threshold probability of a patient in the validation cohort was > 7%, then the nomogram was more beneficial than either indiscriminately treating all or none of the patients.ConclusionWe developed a nomogram based on clinical risk factors that could be used to individually predict pathological intussusceptions in children prior to surgical intervention.

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Intussusception secondary to signet ring cell adenocarcinoma in adolescent

Cited by 4 publications

References 18 publications

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception

Development and Validation of a Nomogram for Predicting Pathological Intussusceptions in Children Prior to Surgical Intervention

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