A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception

Gaskin, David A.; Reid, Alain; O’Shea, Margaret; Gaskin, Pamela S.

doi:10.1155/2022/5271611

Case Reports in Pathology

2022

DOI: 10.1155/2022/5271611

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A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception

David A. Gaskin

Alain Reid

Margaret O’Shea

et al.

Abstract: Signet ring cell carcinoma of the rectum is rare and typically presents with advanced disease. We report a case of a 68-year-old man who presented with left lower quadrant pain and was found to have signet ring cell carcinoma with intussusception. This case is unusual because of its polypoid growth pattern and apparent early pathological stage. We discuss the differential diagnoses and prognosis.

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2024

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Signet-ring colorectal carcinoma

Popovic,

Panic,

Knezevic

et al. 2024

Srp Arh Celok Lek

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Introduction. Colorectal cancer is the third most common cancer worldwide. Signet ring carcinoma is an extremely rare subtype of colorectal cancer, with frequency ranges 0.3-4.6%. The diagnosis of this type of cancer is based on pathohistological analysis. Case outline. A 58-year-old patient was admitted due to abdominal pain and abdominal swelling. The physical findings indicated abdomen above the level of the chest, soft, painfully sensitive in the left hemiabdomen, with positive clinical signs of ascites. Laboratory analyzes indicated: positive inflammatory syndrome, elevation of D-dimer and CA-19.9. Ascites analysis showed the presence of malignant cells. Computed tomography revealed: hepatomegaly, liver steatosis, as well as multiple secondary deposits in the liver, ascites and peritoneal implants. Colonoscopy showed ulceration of the right colon, which was covered with fibrin. The pathohistological findings indicated poorly differentiated, invasive adenocarcinoma of the signet ring carcinoma type. The patient was treated with analgesics, diuretics, proton pump inhibitors, beta 2 blockers, angiotensin converting enzyme inhibitors, low molecular weight heparin, antibiotics and supportive therapy. The patient was discharged after 10 days of hospitalization. He was presented to the multidisciplinary team, which decided on further symptomatic therapy. Conclusion. Signet ring colon cancer is a rare, aggressive tumor with a poor prognosis. Although it is most often localized in the stomach, it is necessary to think about the colorectal localization of this tumor in the differential diagnosis of patients with colonic complaints, especially if they have ?alarm symptoms? and if they are younger.

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Signet-ring colorectal carcinoma

Popovic,

Panic,

Knezevic

et al. 2024

Srp Arh Celok Lek

View full text Add to dashboard Cite

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A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception

Cited by 1 publication

References 21 publications

Signet-ring colorectal carcinoma

Signet-ring colorectal carcinoma

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