Intubation studies of the human small intestine: VII. Factors concerned in absorption of glucose from the jejunum and ileum

Abbott, W. Osler; Karr, Walter G.; Miller, T. Grier

doi:10.1007/bf03000444

Cited by 33 publications

(6 citation statements)

References 14 publications

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“…and for glucose less than 50 mg. per ml., compared to 60 and 150 mg. per ml., respectively, in the test meal. The concentration of glucose in the duodenum is thus in accord with earlier results (36,37), practically never over that of an isotonic solution. The percentage of free fatty acids in the non-phospholipid fat recovered from the intestinal content ( Figure 5) is at all levels around 65 to 70 per cent.…”

Section: Concentration Of Fat Glucose and Protein In The Intestinal supporting

confidence: 92%

Studies of Intestinal Digestion and Absorption in the Human1

Borgström¹,

Dahlqvist²,

Lundh³

et al. 1957

J. Clin. Invest.

993

294

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Section: Concentration Of Fat Glucose and Protein In The Intestinal supporting

confidence: 92%

Studies of Intestinal Digestion and Absorption in the Human1

Borgström¹,

Dahlqvist²,

Lundh³

et al. 1957

J. Clin. Invest.

993

294

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“…The variation between two tests for glucose has been about 25 per cent, and for methionine about 50 per cent; yet the range in absorption rates from subject to subject is much higher. We are thus forced to the conclusion that the main factor in this marked variability is not the fault of the technique itself, but is rather due to actual absorptive differences among individuals (13). From the practical standpoint of the investigator these results would appear to indicate that the method is of chief use in studying those aspects of absorption which can be varied between two consecutive tests.…”

Section: Variability In the Results Of Two Absorptionmentioning

confidence: 99%

Absorption of Glucose and Methionine From the Human Intestine; The Influence of the Glucose Concentration in the Blood and in the Intestinal Lumen

Cummins¹

1952

J. Clin. Invest.

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“…If preferred, the delivery time can be reduced by concentrating the compounds as much as possible. However, it must be noted that hypertonic solutions can influence peristalsis and can increase intestinal secretions ( 102 ), which in turn dilute the infused compound. Increasing the temperature of solutions to 37°C before infusion ( 61 ) could make participants more comfortable than using cold infusions, and warm infusions are less likely to cause GI disturbances ( 103 ).…”

Section: The Use Of Intestinal Catheters In Researchmentioning

confidence: 99%

Using naso- and oro-intestinal catheters in physiological research for intestinal delivery and sampling in vivo: practical and technical aspects to be considered.

Trijp

Wilms

Ríos-Morales

et al. 2021

The American Journal of Clinical Nutrition

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Intestinal catheters have been used for decades in human nutrition, physiology, pharmacokinetics, and gut microbiome research, facilitating the delivery of compounds directly into the intestinal lumen or the aspiration of intestinal fluids in human subjects. Such research provides insights about (local) dynamic metabolic and other intestinal luminal processes, but working with catheters might pose challenges to biomedical researchers and clinicians. Here, we provide an overview of practical and technical aspects of applying naso- and oro-intestinal catheters for delivery of compounds and sampling luminal fluids from the jejunum, ileum, and colon in vivo. The recent literature was extensively reviewed, and combined with experiences and insights we gained through our own clinical trials. We included 60 studies that involved a total of 720 healthy subjects and 42 patients. Most of the studies investigated multiple intestinal regions (24 studies), followed by studies investigating only the jejunum (21 studies), ileum (13 studies), or colon (2 studies). The ileum and colon used to be relatively inaccessible regions in vivo. Custom-made state-of-the-art catheters are available with numerous options for the design, such as multiple lumina, side holes, and inflatable balloons for catheter progression or isolation of intestinal segments. These allow for multiple controlled sampling and compound delivery options in different intestinal regions. Intestinal catheters were often used for delivery (23 studies), sampling (10 studies), or both (27 studies). Sampling speed decreased with increasing distance from the sampling syringe to the specific intestinal segment (i.e., speed highest in duodenum, lowest in ileum/colon). No serious adverse events were reported in the literature, and a dropout rate of around 10% was found for these types of studies. This review is highly relevant for researchers who are active in various research areas and want to expand their research with the use of intestinal catheters in humans in vivo.

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Intubation studies of the human small intestine: VII. Factors concerned in absorption of glucose from the jejunum and ileum

Cited by 33 publications

References 14 publications

Studies of Intestinal Digestion and Absorption in the Human1

Studies of Intestinal Digestion and Absorption in the Human1

Absorption of Glucose and Methionine From the Human Intestine; The Influence of the Glucose Concentration in the Blood and in the Intestinal Lumen

Using naso- and oro-intestinal catheters in physiological research for intestinal delivery and sampling in vivo: practical and technical aspects to be considered.

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