Absorption of Glucose and Methionine From the Human Intestine; The Influence of the Glucose Concentration in the Blood and in the Intestinal Lumen

Cummins, Alvin J.

doi:10.1172/jci102681

Cited by 34 publications

(15 citation statements)

References 8 publications

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“…Thus, extension of the period for calculation of SGU would not have changed the results. Using these criteria, the calculated period for glucose absorption (165Ϯ11 min for controls and 143Ϯ10 min for NIDDM patients) was within the ranges reported in the literature (21)(22)(23). The accuracy of this calculation was further confirmed by the measured values taken during the OG-CLAMP experiments in the same patients (167Ϯ11 min in controls and 149Ϯ10 min in NIDDM patients).…”

Section: Discussionsupporting

confidence: 81%

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

Ludvik

Nolan²,

Roberts³

et al. 1997

J. Clin. Invest.

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The role of splanchnic glucose uptake (SGU) after oral glucose administration as a potential factor contributing to postprandial hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) has not been established conclusively. Therefore, we investigated SGU in six patients with NIDDM and six weight-matched control subjects by means of the hepatic vein catheterization (HVC) technique. In a second part, we examined the applicability of the recently developed OG-CLAMP technique in NIDDM by comparing SGU and first-pass SGU during HVC with SGU during the OG-CLAMP experiment. The OG-CLAMP method combines a euglycemic, hyperinsulinemic clamp and an oral glucose tolerance test (75 g) during steady state glucose infusion (GINF). During HVC, SGU equals the splanchnic fractional extraction times the total (oral and arterial) glucose load presented to the liver. For OG-CLAMP, SGU was calculated as first-pass SGU by subtracting the integrated decrease in GINF over 180 min from 75 g. Cumulative splanchnic glucose output after oral glucose correlated significantly between both methods and was increased significantly in NIDDM patients (73.1 Ϯ 5.1 g for HVC, 76.5 Ϯ 5.5 for OG-CLAMP) compared with nondiabetic patients (46.7 Ϯ 4.4 g for HVC, 57.5 Ϯ 1.9 for OG-CLAMP). Thus, in NIDDM patients, SGU (7.4 Ϯ 2.1 vs. 37.8 Ϯ 5.9% in nondiabetic patients, P Ͻ 0.001) and first-pass SGU (4.7 Ϯ 1.7 vs. 26.5 Ϯ 5.1% in nondiabetic patients, P Ͻ 0.01) were decreased significantly during HVC, as was SGU during OG-CLAMP (3.9 Ϯ 1.7 vs. 23.4 Ϯ 2.5% in nondiabetic patients, P Ͻ 0.0001). SGU measured during OG-CLAMP correlated significantly with SGU ( r ϭ 0.87, P Ͻ 0.05 for NIDDM patients; r ϭ 0.94, P Ͻ 0.01 for nondiabetic patients) and first-pass SGU ( r ϭ 0.87, P Ͻ 0.05 for NIDDM patients; r ϭ 0.84, P Ͻ 0.05 for nondiabetic patients) during HVC. In conclusion, ( a ) SGU after oral glucose administration is decreased in NIDDM as measured by both methods, and (

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Section: Discussionsupporting

confidence: 81%

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

Ludvik

Nolan²,

Roberts³

et al. 1997

J. Clin. Invest.

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“…Glucose disposal rate is largely unaffected [30,42,44]. Time periods for glucose absorption range from 120 to 240min [43][44][45][46] for an OGL with a peak in total glucose at ~40mins [43]. Slower absorption was evidenced in a mixed meal formulation [47], and [30] showed that mixed-meal postprandial GRa increased progressively until near steady-state between 230 and 270 minutes.…”

Section: Variable Enteral Nutrition Modelmentioning

confidence: 99%

Model predictive glycaemic regulation in critical illness using insulin and nutrition input: A pilot study

Wong

Chase

Shaw

et al. 2006

Medical Engineering & Physics

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“…Despite extensive studies of amino acid transport in a variety of preparations, information on amino acid absorption by the human small intestine is limited (6)(7)(8)(9)(10). We studied the pattern of L-methionine absorption in the human small intestine and found differences in transport characteristics between the proximal and distal segments.…”

Section: Introductionmentioning

confidence: 99%

Absorption of l-methionine from the human small intestine

Schedl¹,

Pierce²,

Rider³

et al. 1968

J. Clin. Invest.

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A B S T R A C T Absorption of L-methionine was measured in all parts of the human small intestine using transintestinal intubation and perfusion. In four normal subjects, adsorption was higher in the proximal than in the distal intestine. In two patients with nontropical sprue in relapse, there was a proximal zone of low absorption with higher absorption distally. In all parts of the small intestine, absorption showed rate-limiting kinetics as methionine concentration was increased. In normal subjects, the proximal Km (Michaelis constant) was more than 3 times higher than the distal, which suggests a difference in transport mechanisms between the two segments.

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Absorption of Glucose and Methionine From the Human Intestine; The Influence of the Glucose Concentration in the Blood and in the Intestinal Lumen

Cited by 34 publications

References 8 publications

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

Model predictive glycaemic regulation in critical illness using insulin and nutrition input: A pilot study

Absorption of l-methionine from the human small intestine

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