Introductory Chapter: Some Quantitative Structure Activity Relationship Descriptor

Kandemirli, Fatma

doi:10.5772/intechopen.69642

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Ijpsr (2018) Volume 9 Issue 5 (Research Article)1

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“…To do so we perform Quantitative Structure-Activity Relationship (QSAR) analysis to study the human spleen tyrosine kinase inhibitory activity of a series of flavonoid compounds. The QSAR study is based on the important chemistry principle, which states that similar compounds have similar biological properties 23 . The biological activity of the chemical compounds has correlation with their physicochemical properties, which are known as molecular descriptors 24 .…”

Section: Ijpsr (2018) Volume 9 Issue 5 (Research Article)mentioning

confidence: 99%

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2018

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Spleen tyrosine kinase (Syk) is a member of tyrosine kinase family protein. Syk protein plays a vital role during intracellular signal transduction from high affinity IgE receptor (F cε RI) in allergic reaction. Flavonoids are well known compounds for their anti-allergic properties. In this present work, thirty-four structurally similar flavonoids are investigated as Syk inhibitors by using 3-dimensional quantitative structure-activity relationship (QSAR) models and molecular docking studies. By applying genetic algorithm ( Pharmacokinetics study of chrysin shows that the gastrointestinal absorption of chrysin is high with bioavailability score of 0.55. The current work will help in drug design of human Syk inhibitors and provides information for molecular level of interactions between Syk and the flavonoid group of compounds.

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Section: Ijpsr (2018) Volume 9 Issue 5 (Research Article)mentioning

confidence: 99%

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2018

IJPSR

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Introductory Chapter: Some Quantitative Structure Activity Relationship Descriptor

Cited by 1 publication

References 37 publications

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