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Abstract

Spleen tyrosine kinase (Syk) is a member of tyrosine kinase family protein. Syk protein plays a vital role during intracellular signal transduction from high affinity IgE receptor (F cε RI) in allergic reaction. Flavonoids are well known compounds for their anti-allergic properties. In this present work, thirty-four structurally similar flavonoids are investigated as Syk inhibitors by using 3-dimensional quantitative structure-activity relationship (QSAR) models and molecular docking studies. By applying genetic algorithm ( Pharmacokinetics study of chrysin shows that the gastrointestinal absorption of chrysin is high with bioavailability score of 0.55. The current work will help in drug design of human Syk inhibitors and provides information for molecular level of interactions between Syk and the flavonoid group of compounds.