Introductory Chapter: Human Adenoviruses

Desheva, Yulia

doi:10.5772/intechopen.82554

Cited by 4 publications

(4 citation statements)

References 39 publications

(37 reference statements)

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“…It was postulated that the generated soluble S protein variants are responsible for severe side effects by binding to ACE2-expressing endothelial cells in blood vessels leading to thromboembolic events (DeFrancesco, 2020;Nappi et al, 2021). The vaccine-induced immune thrombotic thrombocytopenia disease mechanism includes the interaction of the SARS-CoV-2 S protein with C-type lectin receptors, heparin sulfate proteoglycans and the CD receptor, and interaction of the adenovirus vector with the CD receptor or platelet factor antibodies (Desheva, 2018). Although some ideas and hypotheses have been presented, the reasons for causing vaccine-induced immune thrombotic thrombocytopenia are still unresolved and require further investigations (Chung et al, 2020).…”

Section: Disadvantages Of Viral Vectorsmentioning

confidence: 99%

“…A third-generation Ad5 serotype vector expressing the SARS-CoV-2 S protein (Ad5-S-nb2) was intramuscularly administered into mice and ferrets, which resulted in protection against challenges with SARS-CoV-2 (Desheva, 2018). Moreover, the Ad5-S-nb2 vaccine provided projection against SARS-CoV-2 in rhesus macaques (Chung et al, 2020).…”

Section: Non-human Adenovirus Vaccinesmentioning

confidence: 99%

See 1 more Smart Citation

An Overview of Adenovirus Vector-based Vaccines against SARS-CoV-2

Zeedan¹,

Abdalhamed²,

Naguib³

et al. 2023

WVJ

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Adenovirus vectors have been employed to develop a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for curtailing the Covid-19 pandemic spreading. Many different viral vectors have been mainly targeting the SARS-CoV-2 spike (S) protein as an antigen. Spike (S) protein is comprised of S1 and S2 subunits, in which the receptor-binding domain (RBD) of S1 is responsible for recognizing and engaging with its host cellular receptor protein angiotensin-converting enzyme 2 (ACE2), S2 accounts for membrane fusion of virus and host cell. Chimpanzee adenovirus was also used as a vector vaccine for SARS-CoV-2 (ChAdSARS-CoV-2-S) by intramuscular injection, and intranasal administration has been tested. Adenovirus vector-based vaccines are the most advanced, with several vaccines receiving Emergency Use Authorization (EUA). It was shown that rhesus macaques were protected from SARS-CoV-2 challenge after a month of being vaccinated with ChAd-SARS-CoV-2-S. A single intranasal or two intramuscular ChAd-SARSCoV-2-S vaccines could induce humoral antibodies and T cell responses to protect the upper and lower respiratory tract against SARS-CoV-2. As the effectiveness was demonstrated in non-human primates, ChAd-SARS-CoV-2-Sa potential option for preventing SARS-CoV-2 infection in humans. However, detecting novel more transmissible and pathogenic SARS-CoV-2 variants added concerns about the vaccine efficacy and needs monitoring. Moreover, the cause of recently documented rare cases of vaccine indicated immune thrombotic thrombocytopenia. This review article provided details for the adenovirus vector vaccine for SARS-CoV-2 in humans and tried to provide solutions to the adenovirus vector hemagglutinin issue.

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Section: Disadvantages Of Viral Vectorsmentioning

confidence: 99%

Section: Non-human Adenovirus Vaccinesmentioning

confidence: 99%

An Overview of Adenovirus Vector-based Vaccines against SARS-CoV-2

Zeedan¹,

Abdalhamed²,

Naguib³

et al. 2023

WVJ

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“…More than 100 different human AdV (HAdV) types have been identified, these serotypes are divided into seven groups (Hashimoto et al, 2018). Nasopharyngeal secretions, faeces, conjunctival discharge, sputum, and urine are all sources of pathogens (Desheva, 2018) mainly in individuals with immunosuppression, Pathogens from the upper respiratory tract are isolated on the 25th day of illness start, Adenoviral infections are spread by the air, where the virus enters the conjunctiva, and possibly through the feces-oral pathway, affecting not just the respiratory tract but also other organs. The incidence of the disease is observed throughout the year, with a peak during the cold season.…”

Section: Introductionmentioning

confidence: 99%

Serological detection of adenovirus infection by ELISA in Fallujah city

Mohamed

Hamad

2022

ijhs

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Adenovirus represent the most common cause of respiratory system disorders and antibody detection can speed up and improve the sensitivity of hAdV diagnosis. Method: This study includes 90 patient who suffering from respiratory symptoms , common colds , or diarrhea with high temperature their ages range from newborn to elderly which collected from Fallujah Maternity and Children's Hospital and teaching hospital in Fallujah in Anbar governorate, for the period from November to May 1-11-2021 to 1-5-2022. Adenovirus was detected by ELISA Test for serum. Results: Out of total 90 serum sample there were 22(24.4%), 68(75.6%) Negative and positive result respectively, from IgG and 87(96.7%) ,3(3.3%) Ne gative and positive result respectively from IgM Result. Conclusion: The presence of positive IgM in ELISA cannot be relied upon as a tool for diagnosing early or acute infections with the virus.

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“…Adenoviruses A, F and G are related to gastrointestinal infections, B and C to respiratory infections and D to keratoconjunctivitis [13]. They can establish latent and persistent infections, with the virus being excreted for weeks after infection and regardless of the primary site of infection [14]. In addition, enteric (HAdV-F40 and 41) and non-enteric HAdV serotypes replicate in the intestine and are potentially capable of being transmitted by contaminated water [9].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity and Quantification of Human Adenoviruses and JC Polyomaviruses in Wastewater Samples

Macena¹,

Vieira²,

Maranhão³

et al. 2021

Int J Plant Anim Environ Sci

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Wastewater-based monitoring has been described as a non-invasive approach to assess virus distribution in a specific geographic area. In this study we assess the genetic diversity and concentration of human adenovirus (HAdV) and human polyomavirus JC (JCPyV) in wastewater samples in Rio de Janeiro, Brazil, during the Olympic Games, Rio 2016.Wastewater samples (50 mL) obtained from domestic and hospital sewages were concentrated by the skimmed milk flocculation method and processed using molecular tools. Quantitative polymerase chain reaction using the ABI PRISM 7500 Real Time TaqMan System and TaqMan Universal Master Mix

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Introductory Chapter: Human Adenoviruses

Cited by 4 publications

References 39 publications

An Overview of Adenovirus Vector-based Vaccines against SARS-CoV-2

An Overview of Adenovirus Vector-based Vaccines against SARS-CoV-2

Serological detection of adenovirus infection by ELISA in Fallujah city

Genetic Diversity and Quantification of Human Adenoviruses and JC Polyomaviruses in Wastewater Samples

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