Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly

Villiers, Melgardt M. de; Otto, Daniel P.; Strydom, Schalk J.; Lvov, Yuri

doi:10.1016/j.addr.2011.05.011

Cited by 353 publications

(262 citation statements)

References 211 publications

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“…18 Subsequently, the method was extended to include single molecules and polyelectrolytes in the following years. 19,20,22,33 In this section we discuss the fabrication details of gold/polymer nanocomposites materials. It is intended to give the reader a ''cooking recipe'' for the layer-by-layer assembly of polyelectrolyte multilayers and gold nanoparticles.…”

Section: Assembly Of Colloid-polyelectrolyte Nanocompositesmentioning

confidence: 99%

Dielectric function of two-phase colloid–polymer nanocomposite

Mitzscherling

Cui

Koopman

et al. 2015

Phys. Chem. Chem. Phys.

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The plasmon resonance of metal nanoparticles determines their optical response in the visible spectral range. Many details such as the electronic properties of gold near the particle surface and the local environment of the particles influence the spectra. We show how the cheap but highly precise fabrication of composite nanolayers by spin-assisted layer-by-layer deposition of polyelectrolytes can be used to investigate the spectral response of gold nanospheres (GNS) and gold nanorods (GNR) in a self-consistent way, using the established Maxwell-Garnett effective medium (MGEM) theory beyond the limit of homogeneous media. We show that the dielectric function of gold nanoparticles differs from the bulk value and experimentally characterize the shape and the surrounding of the particles thoroughly by SEM, AFM and ellipsometry. Averaging the dielectric functions of the layered surrounding by an appropriate weighting with the electric field intensity yields excellent agreement for the spectra of several nanoparticles and nanorods with various cover-layer thicknesses.

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Section: Assembly Of Colloid-polyelectrolyte Nanocompositesmentioning

confidence: 99%

Dielectric function of two-phase colloid–polymer nanocomposite

Mitzscherling

Cui

Koopman

et al. 2015

Phys. Chem. Chem. Phys.

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“…22,23 The coating layers can be fabricated with a thickness in the order of nanometers, enabling the design and engineering of surfaces and interfaces at the molecular level. Originally developed as 24 Using drug crystals or nanoparticle aggregates as core templates for encapsulation is an established application of the LBL nanocoating to control the release of drugs from micro-or nanoparticles. 25,26 For the nanofilms in the present study, we used the anionic polymer, heparin, with a strongly ionic sulphate group in complexation with amine groups of chitosan; this pairing is known to contribute greatly to the stability of the layered nanofilm, 27 making it a very stable coating even under harsh gastric (acidic) conditions.…”

Section: Discussionmentioning

confidence: 99%

Nanolayer encapsulation of insulin- chitosan complexes improves efficiency of oral insulin delivery

Song¹,

Zheng²,

Pickup³

2014

IJN

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Current oral insulin formulations reported in the literature are often associated with an unpredictable burst release of insulin in the intestine, which may increase the risk for problematic hypoglycemia. The aim of the study was to develop a solution based on a nanolayer encapsulation of insulin-chitosan complexes to afford sustained release after oral administration. Chitosan/heparin multilayer coatings were deposited onto insulin-chitosan microparticulate cores in the presence of poly(ethylene) glycol (PEG) in the precipitating and coating solutions. The addition of PEG improved insulin loading and minimized an undesirable loss of the protein resulting from redissolution. Nanolayer encapsulation and the formation of complexes enabled a superior loading capacity of insulin (>90%), as well as enhanced stability and 74% decreased solubility at acid pH in vitro, compared with nonencapsulated insulin. The capsulated insulin administered by oral gavage lowered fasting blood glucose levels by up to 50% in a sustained and dose-dependent manner and reduced postprandial glycemia in streptozotocin-induced diabetic mice without causing hypoglycemia. Nanolayer encapsulation reduced the possibility of rapid and erratic falls of blood glucose levels in animals. This technique represents a promising strategy to promote the intestinal absorption efficiency and release behavior of the hormone, potentially enabling an efficient and safe route for oral insulin delivery of insulin in diabetes management.

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“…The assembly of polyelectrolytes of opposite charge on a solid particle substrate occurs due to the reversal of surface charge with each adsorbed layer. A recent review of LbL self-assembly of nanocoatings is available [100]. Nanoparticles with multilayer polysaccharide shells can be assembled through alternating application of cationic and anionic polysaccharide coatings to a template.…”

Section: Polysaccharide Nanostructures Prepared By Layer-by-layer (Lbmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly

Cited by 353 publications

References 211 publications

Dielectric function of two-phase colloid–polymer nanocomposite

Dielectric function of two-phase colloid–polymer nanocomposite

Nanolayer encapsulation of insulin- chitosan complexes improves efficiency of oral insulin delivery

Self-assembled polysaccharide nanostructures for controlled-release applications

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