Introduction to Modern Liquid Chromatography

Snyder, Lloyd R.; Kirkland, J. J.; Dolan, John W.

doi:10.1002/9780470508183

Cited by 714 publications

(497 citation statements)

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“…The detection and quantification limits (LOD and LOQ, respectively) were determined from the parameters of the calibration curves represented in Table 1, being defined as 3.3 and 10 times the value of the regression error divided by the slope, respectively (Ermer & Miller, 2005;Snyder, Kirkland, & Dolan, 2010).…”

Section: Identification and Quantification Of The Phenolic Compoundsmentioning

confidence: 99%

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L. album L. is far from being understood. In this study, a purified ethanolic extract (PEEL) was prepared and further analyzed by high performance liquid chromatography and electrospray mass spectrometry. Overall, verbascoside accounted for approximately half of the phenolic content of the extract, but this also contained other bioactive phenolic compounds herein detected for the first time in the genus, namely isoscutellarein derivatives. The latter included isoscutellarein-7-O-allosyl(1 →2)glucoside, its O-methyl derivative, three acetyl derivatives of isoscutellarein-Oallosyl glucoside and one acetylated form of O-methylisoscutellarein-7-O-allosyl(1 →2)glucoside. From those, the main isoscutellarein derivative was assigned to isoscutellarein-7-O-(6-O-acetyl-β-allosyl)(1→2)-β-glucoside, as confirmed by NMR. Altogether, isoscutellarein derivatives accounted for almost 30% of PEEL phenolics. Since verbascoside and isoscutellarein derivatives are main components of L. album L. ethanolic extract, their possible association to the health benefits of the plant is discussed.

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Section: Identification and Quantification Of The Phenolic Compoundsmentioning

confidence: 99%

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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“…However, their synthesis procedures used for SPE are mainly based on a non-covalent interactions (such as hydrogen bonds or ionic interactions) between a target molecule (template) and functional monomers that polymerize in a porogen solvent in the presence of a cross-linker and initiator. Once the template is removed, selective molecular recognition sites often described as three-dimensional shapes in the polymer are available for the selective rebinding of the target molecule and some structurally related compounds [16,17].…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.

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“…For example, the four most popular organic solvents used in petroleum fields are xylene, kerosene, toluene and hexane [6]. Considering liquid chromatography coupled to ICP, acetonitrile andmethanol are the major solvents used in mobile phases.Other solvents such asethanol, isopropanol, hexane, methylene chloride and tetrahydrofuran can also be encountered [57].…”

Section: Physico-chemical Properties Of Organic Solvents and Associatmentioning

confidence: 99%