Introduction to Dorsal Root Ganglion Stimulation an Overview of the Field

Scarfo, Keith-Austin; Strand, Natalie; Hunter, Corey; Deer, Timothy R.

doi:10.1007/978-3-030-84778-4_6

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Current indications for SCS include post-laminectomy syndrome, back pain, and numerous other chronic pain conditions [ 20 ]. DRG-S has similar indications and has been found to be more efficacious than SCS for focal neuropathies and complex regional pain syndrome (CRPS) [ 21 , 22 ]. Likewise, PNS has indications for neuropathic pain and is best utilized when symptoms can be traced to a specific nerve [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation for Peripheral Nerve Regeneration: Systematic Review of Mechanisms and In Vivo Highlights

et al. 2023

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While denervation can occur with aging, peripheral nerve injuries are debilitating and often leads to a loss of function and neuropathic pain. Although injured peripheral nerves can regenerate and reinnervate their targets, this process is slow and directionless. There is some evidence supporting the use of neuromodulation to enhance the regeneration of peripheral nerves. This systematic review reported on the underlying mechanisms that allow neuromodulation to aid peripheral nerve regeneration and highlighted important in vivo studies that demonstrate its efficacy. Studies were identified from PubMed (inception through September 2022) and the results were synthesized qualitatively. Included studies were required to contain content related to peripheral nerve regeneration and some form of neuromodulation. Studies reporting in vivo highlights were subject to a risk of bias assessment using the Cochrane Risk of Bias tool. The results of 52 studies indicate that neuromodulation enhances natural peripheral nerve regeneration processes, but still requires other interventions (e.g., conduits) to control the direction of reinnervation. Additional human studies are warranted to verify the applicability of animal studies and to determine how neuromodulation can be optimized for the greatest functional restoration.

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