Introduction

Ef, La Gamma

doi:10.1053/j.semperi.2008.09.001

Cited by 8 publications

(2 citation statements)

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“…Transient hypothyroxinaemia of prematurity (THOP), characterised by low thyroxine (T4) levels with normal or low thyroid stimulating hormone levels, occurs in more than half of the extremely low birth weight infants (ELBWIs) born at <30 weeks 1,2 . The low T4 levels reach a nadir at 7–10 days postnatal and could remain low for the first 3–6 weeks of the postnatal period, depending on the extent of prematurity 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Incidence and severity of transient hypothyroxinaemia of prematurity associated with survival without composite morbidities in extremely low birth weight infants

Yoon

Chang

Ahn

et al. 2019

Sci Rep

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This study investigated the incidence of transient hypothyroxinaemia of prematurity (THOP) associated with survival without composite morbidities and the predictability of THOP severity in extremely low birth weight infants (ELBWIs). We retrospectively reviewed the medical records of 546 ELBWIs who underwent initial thyroid function tests within 14 postnatal days, with 156 ELBWIs from 2000 to 2005 (period I) and 390 from 2006 to 2013 (period II). The infants were stratified into 23–24, 25–26 and 27–28 weeks’ gestation subgroups within each period; the initial thyroxine (T4) level, mortality, clinical characteristics and composite morbidities, including bronchopulmonary dysplasia, intraventricular haemorrhage, necrotizing enterocolitis, and retinopathy of prematurity were analysed. The predictive value of the initial T4 level, Apgar score at 5 min, and clinical risk index for babies II (CRIB II) score for estimating mortality and survival with or without composite morbidities was assessed. Comparing period II and period I, the incidence of THOP was significantly decreased along with significantly increased survival without composite morbidities in ELBWIs at 25–28 weeks’ gestation. The severity of THOP showed significant associations with mortality and composite morbidities. The initial T4 level was most effective for predicting outcome compared with Apgar and CRIB II scores.

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Section: Introductionmentioning

confidence: 99%

Incidence and severity of transient hypothyroxinaemia of prematurity associated with survival without composite morbidities in extremely low birth weight infants

Yoon

Chang

Ahn

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Hypothyroxinemia of prematurity (HOP) is a transient alteration in thyroid hormone availabilityfound in more than half of extremely low birth weight infants (ELBW) born at less than 30 weeks [ 1 ]. HOP is characterized by very low total T4 (TT4) and free T4 (FT4) levels with a normal or low thyroid stimulating hormone (TSH); TT4 and FT4 show a nadir at 7-10 days of life and they may remained low for the first 3-6 weeks of life depending from the severity of prematurity[ 2 ].…”

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confidence: 99%