Hypothyroxinemia in extremely low birth weight infants

Ghirri, Paolo; Dini, Francesca; Lunardi, Sara; Moscuzza, Francesca; Boldrini, Antonio

doi:10.1186/1824-7288-41-s1-a16

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…in preterm neonates such as intraventricular hemorrhage(IVH), neurodevelopmental delay, deficits in cognitive, motor, languages, attention and memory [9], particularly severe hypothyroxinemia which could be associated with a poor outcome in premature babies.…”

Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

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2018

AJPN

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Introduction: Immaturity of hypothalamus-pituitary-thyroid axis in preterm infants causes the low level of thyroxin hormone and hypothyroxinemia of prematurity (HOP). In our country, Iran TSH that is measured by filter paper is the only laboratory test for screening of hypothyroidism and the missing of the HOP is concerning. This research was done to evaluate the rate of HOP. Material and Methods:This prospective-descriptive study was conducted in 2017 in our hospital. In the participants included preterm infants with gestational age ≤34 weeks or birth weights ≤2000 grams, measurement of TSH and T4 were done by blood sampling instead of filter paper and the values of thyroid function tests were analyzed. Results:In total 475 preterm newborns in the first sampling and 203 cases in the second one were enrolled, 236(49.7%) neonates were male. Mean gestational age and birth weight were 31.46weeks and 1522.59 grams respectively. In overall, in the first blood sampling, 100 of 475(21%) preterm infants had low T4 ( 13.1% related to HOP and 8.3% belonged to hypothyroidism) , but in second sampling, in the 50 from 203 cases (24.7%), the low levels of T4 were observed ( 14.2% related to HOP and 10.3% belonged to hypothyroidism).In comparisons the values of T4 in both of sampling: in 24 cases (11.8%) persistent hypothyroxinemia ,26(12.8%) delayed hypothyroxinemia and in 29(14.2%) transient forms of hypothyroxinemia were detected. Conclusion:Our research resulted that the rate of HOP is remarkable and measurement of T4 in the screening of preterm infants is recommended.

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Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

Untitled

2018

AJPN

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Hypothyroxinemia in extremely low birth weight infants

Cited by 1 publication

References 8 publications

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