Introduction of lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) into the male homosexual community in Amsterdam.

Coutinho, R. A.; Krone, W; Smit, L.; Lent, P Albrecht-van; Noordaa, J. van der; Schaesberg, W; Goudsmit, Jaap

doi:10.1136/sti.62.1.38

Cited by 14 publications

(9 citation statements)

References 12 publications

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“…An ELISA using purified HIV (strain HTLV-IIIB) as antigen (Vironostika, Organon, Oss, The Netherlands) was used to detect anti-HIV antibodies (13). Specificity of the antibody for HIV as confirmed by immunoblotting (14) was defined as reactivity with the major core protein (p24) and/or the transmembrane protein (gp4l).…”

Section: Methodsmentioning

confidence: 99%

Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

Goudsmit

Epstein

Paul

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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Section: Methodsmentioning

confidence: 99%

Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

Goudsmit

Epstein

Paul

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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“…We assume that these are early postseroconversion samples, both because it has been estimated that the virus was introduced into the Amsterdam homosexual community in the late 1970s or early 1980s (19) and because two of them were associated with an acute HIV-like syndrome. Fifteen samples taken from each of the years 1985 and 1990 were used from participants in the Amsterdam cohort ofhomosexual men (17).…”

mentioning

confidence: 99%

Increasing antigenic and genetic diversity of the V3 variable domain of the human immunodeficiency virus envelope protein in the course of the AIDS epidemic.

Kuiken

Zwart

Baan

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

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Population-wide variation in genomic RNA of human immunodeficiency virus type 1 (HIV-1) encompassing the V3 loop of the envelope protein was studied in serum samples of 74 newly infected individuals from three Dutch cohorts: 30 homosexual men, 32 drug users, and 12 hemophiliacs. During acute infection, HIV-1 RNA sequences present in serum are relatively homogeneous, which makes direct sequencing feasible. This offered an opportunity to study the infecting virus variants before mutations had accumulated in the new host. The sampling dates ranged from 1980 to 1991, thus spanning the entire AIDS epidemic in the Netherlands. The diversity in the sequenced region increased over time in both the homosexual and the drug-user risk groups. Furthermore, this increase was associated with an increase in antigenic variation, as witnessed by serum reactivity to a V3 peptide panel. Despite this diversification, some 1990 sequences still closely resembled the earliest 1980 sequence, making ancestral inferences problematic. No evidence was found of a change in the master sequence of the virus quasispecies over time. At the amino acid level, no risk-group-associated variation was found, but at the nudeotide level, the drug-user and homosexual/hemophiliac sequences could be distinguished on the basis ofa single silent nucleotide change in the sequence encoding the tip of the V3 loop. Hemophiliac sequences could not be distinguished from those of homosexuals. In spite of the large and increasing genetic variability, all sequences were more similr to the European/American HIV consensus sequence than to that of non-Western strains.The envelope protein of human immunodeficiency virus type I (HIV-1) contains five variable domains (V1-V5) separated by relatively conserved regions. The viral genome, and especially the envelope gene, is characterized by a high potential for variation without loss of functionality (e.g., ref.

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“…However, the approximate time of seroconversion can be estimated. Introduction of HIV-1 in the male homosexual community in Amsterdam occurred at the end of the 1970s and was spread considerably since 1982 [28]. The first American haemophiliacs were found seropositive in 1979 and the majority developed HIV-1-Ab from 1981 to 1982, while HIV-1-Ab conversion in French haemophilicas also started in 1979 and peaked in 1982 until 1984 [2,29-301.…”

Section: Discussionmentioning

confidence: 99%

Low AIDS Attack Rate Among Dutch Haemophiliacs Compared to Homosexual Men: A Correlate of HIV Antigenaemia Frequencies

Wolfs¹,

Wolf²,

Breederveld

et al. 1989

Vox Sanguinis

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A cohort of 180 haemophiliacs followed between 1983 and 1986 and a cohort of 961 homosexual men followed between 1984 and 1986 were compared for the prevalence and incidence of HIV-1 antibody (HIV-1-Ab) seropositivity, the incidence of AIDS-related complex (ARC) and AIDS and the prevalence and incidence of serological and immunological markers for HIV-related disease progression. Among the haemophiliacs 23 (12.8%) patients were HIV-1-Ab seropositive at entry and 20 (12.7%) of the remaining 157 seroconverted for HIV-1-Ab during follow-up. Of the homosexual men 238 (24.8%) were HIV-1-Ab seropositive at entry and 68 (9.4%) of the 723 at entry seronegatives seroconverted during follow-up. Clinical follow-up of the HIV-1-Ab seropositive and seroconverted men was 59 months in the haemophiliac cohort and 60 months in the homosexual cohort. Among the HIV-1-Ab seropositive and seroconverted haemophiliacs and homosexual men the cumulative ARC/AIDS incidence was 2 and 18%, respectively. Occurrence of HIV-1-antigenaemia was more frequent among seropositive and seroconverted homosexual men (28%) than among haemophiliacs (7%) (p = 0.001). The groups did not differ significantly for the absence or loss of anti-HIV core antibodies or the occurrence of low CD4+ cell numbers. These data indicate a slower progression of HIV-related disease in seropositive haemophiliacs compared to seropositive homosexual men.

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Introduction of lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) into the male homosexual community in Amsterdam.

Cited by 14 publications

References 12 publications

Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

Increasing antigenic and genetic diversity of the V3 variable domain of the human immunodeficiency virus envelope protein in the course of the AIDS epidemic.

Low AIDS Attack Rate Among Dutch Haemophiliacs Compared to Homosexual Men: A Correlate of HIV Antigenaemia Frequencies

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