Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules

Niederquell, Andreas; Völker, Andreas Charles; Kuentz, Martin

doi:10.1016/j.ijpharm.2012.01.042

Cited by 24 publications

(14 citation statements)

References 37 publications

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“…17,18 This technique is being increasingly employed in the field of food science, 2,9 for instance, to follow gelation or acidification, 19,20 as well as to monitor destabilization mechanisms, such as flocculation and/or creaming or Ostwald ripening. [21][22][23] DWS has only recently been introduced into the pharmaceutical field, 24 but to the best of our knowledge not for monitoring of a pharmaceutical manufacturing process.…”

Section: Introductionmentioning

confidence: 99%

Introducing Diffusing Wave Spectroscopy as a Process Analytical Tool for Pharmaceutical Emulsion Manufacturing

Reufer

Machado

Niederquell

et al. 2014

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Introducing Diffusing Wave Spectroscopy as a Process Analytical Tool for Pharmaceutical Emulsion Manufacturing

Reufer

Machado

Niederquell

et al. 2014

Journal of Pharmaceutical Sciences

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“…Higher zeta potential shows a better constancy of the formulation. Generally, the value of zeta meter system is negative as a result of the free unsaturated fats yet when cationic lipid [62,63]. For example, oleylamine is utilized, the charge contains the property of interfacing successfully with the mucosal surface of the GIT and these interchanges are electrostatic nature because of which solid adhesion can be estimated with improved absorption [36,64].…”

Section: (8) Characterization and Evaluation Of Smeddsmentioning

confidence: 99%

Review of formulation and evaluation of self-micro emulsifying drug delivery system (SMEDDS)

Bahadur¹,

Yadu²,

Baghel³

et al. 2020

ScienceRise: Pharmaceutical Science

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Approximately half of the new drug applicants that reach formulation have poor water solubility. Oral delivery has been the main route of drug administration for the chronic treatment of numerous diseases. In different cases, in oral conveyance, 50 % of the medication compound is hampered because of the high lipid soluble or fat soluble of the medication itself. Around 40 % of new drug applicants show low solubility in water, which prompts poor oral bioavailability, high Intra and Intersubject changeability, and deficiency of dose proportionality Aim of review. The main aim of this review article is to gather the information related to design and evaluation of SMEDDS. These information can be utilized to enhance the bioavailability of the poorly aqueous soluble drug for various types of orally administered drugs. In this review article, various literature are reviewed and summerised in single paper to serve as reference guide to various research scholars and researchers working on self-micro-emulsifying drug delivery systems. Materials and Methods. To prepare this manuscript various keywords were searched in different search engine such as Google, Yahoo and Bing etc. This review article reviews the recent work done in the field of SMEDDS. It comprises review of literatures available in public domain and formulation of SMEDDS and its characterization is summarized in this article. Result. The various strategies to developed poor aqueous soluble drug for improvement of bioavailability for example, salt development and molecular size reduction of the compound might be one technique to enhance the dissolution rate of the drug. In any case, these methods have their limitations. SMEDDS is one of the novel applications for the delivery of low water soluble and low bioavailability of drug. SMEDDS is a method to improve the aqueous solubility of the medication; SMEDDS are described as isotropic blenders of oils, surfactants, and co-surfactant. Upon slightly stir followed by dilution with distilled water, for example, gastrointestinal liquids, these techniques can define clear o/w micro emulsion. SMEDDS is first choice and key technology for developing the lipophilic drug and other different factors that chance to affect the oral bioavailability. Conclusions. This review paper attempts to describe the preparation of SMEDDS and furthermore discusses the development of pseudo ternary phase diagram for SMEDDS. It describes the mechanism and method of preparation involved in SMEDDS. The capability of oral absorption of drug compound from the SMEDDS relies upon numerous formulation−related parameters, for example, surfactant concentration, oil/surfactant ratio, and hydrophobicity of emulsion, globule size and charge, in vitro, in vivo all of which basically characterized the ability of self-emulsification. SMEDDS are administered as unit dosage form and it also protect the degradation of drug.

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“…Por lo tanto, la viscosidad de la formulación debe permitir la incorporación del medio acuoso para que pueda ocurrir la dispersión. El llenado de formulaciones de baja viscosidad en cápsulas duras puede provocar la pérdida de masa de relleno debido a las salpicaduras alrededor de la boquilla de dosificación de la máquina, lo que puede llevar a fugas o una variabilidad en el peso de las unidades [153].…”

Section: Cápsulasunclassified

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

Cueto

Ortega

Sotomayor

2019

Rev. Colomb. Cienc. Quím. Farm.

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Los grandes avances tecnológicos en la industria farmacéutica, que involucran el uso de la química combinatoria y el cribado de alto rendimiento, han conllevado al descubrimiento de muchas entidades químicas candidatas a fármacos que presentan baja solubilidad acuosa, debido a su elevada complejidad molecular, lo que hace difícil el desarrollo de productos con estas sustancias. Los sistemas de entrega de fármacos autoemulsificables (SEDDS) han generado un interés para el desarrollo farmacéutico porque son una alternativa efectiva para mejorar la biodisponibilidad de fármacos poco solubles en agua. Para describir el estado de conocimiento sobre estos sistemas se realizó una revisión sistemática en diferentes bases de datos sobre la literatura relacionada con los SEDDS a nivel nacional e internacional, logrando así describir los aspectos más relevantes sobre los SEDDS (tipos, composición, mecanismos para aumentar biodisponibilidad, caracterización, formulaciones). A pesar de las numerosas investigaciones realizadas durante los últimos años que muestran el potencial de los SEDDS para mejorar la biodisponibilidad de los fármacos poco solubles en agua, se pudo evidenciar que solo algunas sustancias activas han sido incluidas en estos sistemas y comercializadas exitosamente, esto debido a algunas limitaciones que indican la necesidad de un mayor entendimiento sobre estos sistemas.

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Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules

Cited by 24 publications

References 37 publications

Introducing Diffusing Wave Spectroscopy as a Process Analytical Tool for Pharmaceutical Emulsion Manufacturing

Introducing Diffusing Wave Spectroscopy as a Process Analytical Tool for Pharmaceutical Emulsion Manufacturing

Review of formulation and evaluation of self-micro emulsifying drug delivery system (SMEDDS)

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

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