Introduction and Interpretation of Flavonoids

Muhaisen, Hasan M. H.

doi:10.1166/asem.2014.1630

Cited by 5 publications

(2 citation statements)

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“…A large variety of edible plant species contains flavonoids, which are considered to be important human dietary constituents [ 12 , 13 ]. Flavonoids are among the most abundant and widespread secondary metabolites groups, which is extremely valuable to mankind, not merely because of their contribution to imparting plant colors, but also due to its several physiologically active members too [ 14 ]. The confirmation of flavonoid’s reliable positive benefits like cancer prevention has produced a considerable interest in research, including serving foods containing flavonoids [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

2021

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Background Natural plants and plant-derived formulations have been used by mankind from the ancient period of time. For the past few years, many investigations elaborated the therapeutic potential of various secondary chemicals present in the plants. Literature revealed that the various secondary metabolites, viz. phenolics and flavonoids, are responsible for a variety of therapeutic action in humans. Main body In the present review, an attempt has been made to compile the exploration of natural phenolic compounds with major emphasis on flavonoids and their therapeutic potential too. Interestingly, long-term intake of many dietary foods (rich in phenolics) proved to be protective against the development and management of diabetes, cancer, osteoporosis, cardiovascular diseases and neurodegenerative diseases, etc. Conclusion This review presents an overview of flavonoid compounds to use them as a potential therapeutic alternative in various diseases and disorders. In addition, the present understanding of phenolics and flavonoids will serve as the basis for the next scientific studies.

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Section: Introductionmentioning

confidence: 99%

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

2021

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“…Other significant components are prenylated flavanols (prenyl-urucuol A, prenyl-isotirumalin and prenylutilinol), prenylated flavones (3′-methoxylupinifolin), prenylated flavanones (2S)-6-(γ,γdimethylallyl)-5,4′-dihydroxy-3′-methoxy-6″, 6″-dimethylpyran [2″,3″:7,8] flavanone, and prenylutiline, chalcones (4-hydroxylonchocarpin), and stilbenes (lonchocarpene, methoxylonchocarpene, 3,5-dimethoxy-4-O-prenyl-cis-stilbene and 3,5-dimethoxy-4-hydroxy-3prenyl-trans-stilbene). The structures are organized [40] and summarized in Figure 1. The biological activity of these components, experimentally tested by different authors, is summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Promising Potential of Lonchocarpus utilis against South American Myasis

Luzuriaga-Quichimbo

Salas

Cerón-Martínez

et al. 2019

Plants

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Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine).

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