Promising Potential of Lonchocarpus utilis against South American Myasis

Abstract

Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine).

A medicina tradicional Amazônica: uma revisão sistemática da literatura

“…Outros estudos tratam do efeito terapêutico das plantas medicinais a partir do etnoconhecimento para as mais diversas condições de saúde, como ansiedade e depressão, edema, dor de cabeça, Parkinson, tratamento de distúrbios alimentares, miíase, déficits cognitivos em epilepsia e demência, doenças do sistema nervoso e disfunção sexual (Berlowitz et al, 2023;Almeida Junior et al, 2021;Albino et al, 2021;Katchborian-Neto et al, 2020;Renelli et al, 2020;Luzuriaga-Quichimbo, 2020;McKenna et al, 2011;Siqueira et al, 2007;Batista et al, 2023).…”