Introduction

Karthik, M. V. K.; Shukla, Pratyoosh

doi:10.1007/978-1-4614-4723-8_1

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…The interaction of host and pathogen in plants plays an important role in enhancing signaling cascade which brings change in the protein and eventually in the phenotypic expression. There are few notable studies on systems biology and molecular modeling tools to understand the microbial enzymes and similar proteins, but it lacks any further scope for studies of proteins involved in plant–microbe interaction ( Singh and Shukla, 2011 , 2015 ; Karthik and Shukla, 2012 ; Baweja et al, 2015 , 2016 ; Singh et al, 2016 ). The study of in silico transcriptomes of both host and pathogen during the infection will contribute to the knowledge of changes occurring during the infection.…”

Section: Systems Biology Approaches In Plant–microbe Interactionsmentioning

confidence: 99%

Recent Developments in Systems Biology and Metabolic Engineering of Plant–Microbe Interactions

et al. 2016

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Microorganisms play a crucial role in the sustainability of the various ecosystems. The characterization of various interactions between microorganisms and other biotic factors is a necessary footstep to understand the association and functions of microbial communities. Among the different microbial interactions in an ecosystem, plant–microbe interaction plays an important role to balance the ecosystem. The present review explores plant–microbe interactions using gene editing and system biology tools toward the comprehension in improvement of plant traits. Further, system biology tools like FBA (flux balance analysis), OptKnock, and constraint-based modeling helps in understanding such interactions as a whole. In addition, various gene editing tools have been summarized and a strategy has been hypothesized for the development of disease free plants. Furthermore, we have tried to summarize the predictions through data retrieved from various types of sources such as high throughput sequencing data (e.g., single nucleotide polymorphism detection, RNA-seq, proteomics) and metabolic models have been reconstructed from such sequences for species communities. It is well known fact that systems biology approaches and modeling of biological networks will enable us to learn the insight of such network and will also help further in understanding these interactions.

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Section: Systems Biology Approaches In Plant–microbe Interactionsmentioning

confidence: 99%

Recent Developments in Systems Biology and Metabolic Engineering of Plant–Microbe Interactions

et al. 2016

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“… Singh and Shukla, 2015 summarize techniques and software to analyze the metagenomic data. Furthermore, studies on computational enzyme docking also elucidated the characterization of the efficient substrates for the enzymes ( Karthik and Shukla, 2012 ; Singh and Shukla, 2012 ; Karumuri et al, 2015 ; Singh et al, 2016 ).…”

Section: Mining Of the Novel Genes Encoding The Target Enzyme Or Protmentioning

confidence: 99%

Current Technological Improvements in Enzymes toward Their Biotechnological Applications

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Enzymes from extremophiles are creating interest among researchers due to their unique properties and the enormous power of catalysis at extreme conditions. Since community demands are getting more intensified, therefore, researchers are applying various approaches viz. metagenomics to increase the database of extremophilic species. Furthermore, the innovations are being made in the naturally occurring enzymes utilizing various tools of recombinant DNA technology and protein engineering, which allows redesigning of the enzymes for its better fitment into the process. In this review, we discuss the biochemical constraints of psychrophiles during survival at the lower temperature. We summarize the current knowledge about the sources of such enzymes and their in vitro modification through mutagenesis to explore their biotechnological potential. Finally, we recap the microbial cell surface display to enhance the efficiency of the process in cost effective way.

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Introduction

Cited by 2 publications

References 24 publications

Recent Developments in Systems Biology and Metabolic Engineering of Plant–Microbe Interactions

Recent Developments in Systems Biology and Metabolic Engineering of Plant–Microbe Interactions

Current Technological Improvements in Enzymes toward Their Biotechnological Applications

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