Introducing photo-crosslinked bio-nanocomposites based on polyvinylidene fluoride/poly(glycerol azelaic acid)-g-glycidyl methacrylate for bone tissue engineering

Abstract

As a glycerol-based polyester, poly(glycerol azelaic acid) (PGAz) has shown a great potential for biomedical applications, such as tissue engineering. However, it tends to show low mechanical strength and a...

Harnessing the power of polyol-based polyesters for biomedical innovations: synthesis, properties, and biodegradation

“…For instance, it has been shown that PVDF can considerably impact the crystallization of PCL in the PVDF/PCL blend, which in turn can affect the hydrolytic degradation of the PCL phase. 192 In yet another work, Fakhri et al 36 reported that the hydrolytic degradation of poly(glycerol azelaic acid) (PGAz) was diminished after blending with PVDF. The primary reason for this reduction was the presence of the hydrophobic semi-crystalline PVDF phase, which hindered water molecules from accessing the hydrolytically unstable bonds in PGAz.…”

“…28 For instance, by manipulating factors like polymer composition, molecular weight, and crystallinity, it is possible to modulate the mechanical strength, degradation rate, and porosity of the scaffold, making it suitable for the targeted tissue. 36,42,48 One of the major advantages of using polyol-based polyesters in TE is their capacity to incorporate bioactive molecules and growth factors, which can further enhance cell interaction and regeneration. 87,211 These biopolymers can be functionalized or blended with other materials, such as hydrogels, to improve their biological performance and control the release of incorporated bioactive agents.…”

“…Poly(glycerol-azelaic acid) (PGAz) is a polyol-based polyester that has been investigated for its potential use in regenerative medicine. 81 In a recent study, Fakhri et al 36 developed photo-curable PGAz-based scaffolds tailored for cancellous bone TE applications. The researchers first introduced glycidyl methacrylate (GMA) moieties onto the PGAz backbone to create a UV-curable PGAz- g -GMA (PGAG) resin.…”

“…35 Furthermore, loss of mechanical functionality and integrity must be taken into account to ensure device efficacy and longevity. 36…”

Soybean oil‐based nanocomposites for dye adsorption: AESO‐chitosan‐graphene oxide synergy in water treatment

“…To create adsorbent films with approximate thicknesses of 0.45 mm, the solutions were cast into a Teflon mold and cross-linked under a UV lamp (OmniCure, S2000, λ = 360-380 nm, 10 cm working distance), as reported in a previous study. 40 Each side of the prepared films was exposed to UV irradiation for 15 min. Notably, for adsorption experiments, A-C2 was selected for the fabrication of adsorbents comprising 1%, 2%, and 3% GO nanoparticles, as it exhibited superior adsorption properties compared to A-C4 and A-C6.…”