Introducing PHIL (precipitating hydrophobic injectable liquid) – a new embolic agent for the body interventional radiologist

Prashar, Akash; Butt, Saqib; Shaida, Nadeem

doi:10.5152/dir.2019.19063

Cited by 16 publications

(18 citation statements)

References 7 publications

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“…Squid (Squid-Peri, Emboflu, Gland, Switzerland) is a relatively new non-adhesive liquid embolic agent which has mainly also been used in the cerebral district [ 12 ] with some recent application in the abdominal district [ 13 ]. PHIL (MicroVention, Tustin, CA, USA) and Easyx (MicroVention, Tustin, CA, USA) are the latest liquid embolic agents to appear on the market for which there is not already solid literature available [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Adhesive Liquid Embolic Agents in Extra-Cranial District: State of the Art and Review of the Literature

Piacentino

Fontana

Curti

et al. 2021

JCM

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This review focuses on the use of “new” generation of non-adhesive liquid embolic agents (NALEA). In literature, non-adhesive liquid embolic agents have mainly been used in the cerebral district; however, multiple papers describing the use of NALEA in the extracranial district have been published recently and the aim of this review is to explore and analyze this field of application. There are a few NALEA liquids such as Onyx, Squid, and Phil currently available in the market, and they are used in the following applications: mainly arteriovenous malformations, endoleaks, visceral aneurysm or pseudoaneurysm, presurgical and hypervascular lesions embolization, and a niche of percutaneous approaches. These types of embolizing fluids can be used alone or in combination with other embolizing agents (such as coils or particles) so as to enhance its embolizing effect or improve its possible defects. The primary purpose of this paper is to evaluate the use of NALEAs, predominantly used alone, in elective embolization procedures. We did not attempt a meta-analysis due to the data heterogeneity, high number of case reports, and the lack of a consistent follow-up time period.

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Section: Introductionmentioning

confidence: 99%

Non-Adhesive Liquid Embolic Agents in Extra-Cranial District: State of the Art and Review of the Literature

Piacentino

Fontana

Curti

et al. 2021

JCM

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“…PHIL is an established treatment option in interventional neuroradiology for the embolization of cerebral and spinal arteriovenous malformations and dural fistulae. It is also increasingly being used in body intervention [5] . Liquid embolic agents such as PHIL have several advantages over traditional coiling and particulate-based embolization techniques: they solidify when injected into the vasculature, providing a superior mould of their target area's geometry compared to coiling; the processes of solidification and occlusion are independent of the patient's physiology, allowing their use in patients with coagulopathies and patients receiving anti–coagulation treatment; and they are considered less likely to fragment and migrate than particulate-based embolic materials.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary migration of liquid embolization material: An unusual cause of pulmonary embolism

Yeomans

Sastry

Marin

2022

Radiology Case Reports

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Iatrogenic non–thrombotic pulmonary embolism is a rare cause of pulmonary embolism. This case demonstrates the unusual imaging findings associated with pulmonary migration of Precipitating Hydrophobic Injectable Liquid, a liquid embolization material most commonly used in interventional neuroradiological procedures. Chest X-ray and CT Pulmonary Angiogram images are shown. The case highlights the importance of a thorough clinical history, including past medical history, when interpreting radiological studies.

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“…A variety of agents have been used in the management of auricular AVMs, including ethanol, 11,17 N–butyl cyanoacrylate (NBCA), 29,44,45 Onyx, 8,44 precipitating hydrophobic injectable liquid (PHIL), 46 polyvinyl alcohol (PVA) particles, 35 coils, 10,17,42,47 and gelatin sponge 12,48 . The characteristics, drawbacks, and clinical applications of these agents are summarized in Table 4 7,10,11,16,17,29,42,44,47–66 . Among these embolic agents, ethanol is the only agent that can provide permanent embolization of AVMs, but its risk and high technical requirements limit its wide application 11,17,67 .…”

Section: Discussionmentioning

confidence: 99%

“…12,48 The characteristics, drawbacks, and clinical applications of these agents are summarized in Table 4. 7,10,11,16,17,29,42,44,[47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66] Among these embolic agents, ethanol is the only agent that can provide permanent embolization of AVMs, but its risk and high technical requirements limit its wide application. 11,17,67 Other embolic agents are generally used for hemostasis of acute bleeding and palliative embolization when used alone, due to the possibility of vascular recanalization.…”

Section: Surgical Resection Combined With Endovascular Treatmentmentioning

confidence: 99%

Surgical management of auricular arteriovenous malformations: A literature review

Liu

Chen

Jia

et al. 2022

Laryngoscope Investig Oto

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Auricular arteriovenous malformations (AVMs) can cause a variety of symptoms that seriously impact the patient's appearance, life, and mental well-being. Surgery is the primary management method for auricular AVMs, but there is no consensus on how to surgically manage auricular AVMs. In this article, we document a comprehensive review of the characteristics, classification, and surgical interventions to treat auricular AVMs.

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Introducing PHIL (precipitating hydrophobic injectable liquid) – a new embolic agent for the body interventional radiologist

Cited by 16 publications

References 7 publications

Non-Adhesive Liquid Embolic Agents in Extra-Cranial District: State of the Art and Review of the Literature

Non-Adhesive Liquid Embolic Agents in Extra-Cranial District: State of the Art and Review of the Literature

Pulmonary migration of liquid embolization material: An unusual cause of pulmonary embolism

Surgical management of auricular arteriovenous malformations: A literature review

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