Intrinsic functional connectivity alteration of dorsal and rostral anterior cingulate cortex in obsessive-compulsive disorder: A resting fMRI study

Zhang, Zongfeng; Fan, Qing; Zhu, Yajing; Tan, Lian; Chen, Yongjun; Gao, Rui; Zhang, Haiyin; Li, Yao; Xiao, Zeping

doi:10.1016/j.neulet.2017.06.026

Cited by 17 publications

(12 citation statements)

References 20 publications

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“…We speculate that the OFC FC alterations are not sensitive to the resting state imaging protocol used in our study but that they could be unmasked by functional activation in symptom provocation protocols as in previous studies (69,70). Importantly, both increased and reduced FC has been reported by several previous studies for ACC, the constituent of affective CSTC loop (20,71,72). The reduced ACC FC with the areas of the limbic/temporal cortex in our sample is in line with recent meta-analysis revealing consistent decreased ACC connectivity with limbic areas (62), temporal cortex, and OFC (61), as well as with the hypoconnectivity within the major brain networks identified by recent meta-analysis (24).…”

Section: Fc Alterations In the Ocd Samplesupporting

confidence: 91%

Functional Connectivity Changes in Obsessive–Compulsive Disorder Correspond to Interference Control and Obsessions Severity

et al. 2020

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Introduction: Deficits in neurocognitive mechanisms such as inhibition control and cognitive flexibility have been suggested to mediate the symptoms in obsessive-compulsive disorder (OCD). These mechanisms are proposedly controlled by the "affective" and "executive" orbitofronto-striato-thalamo-cortical (CSTC) circuits with well-documented morphological and functional alterations in OCD that are associated with OCD symptoms. The precuneus region has been suggested in OCD as another key structure associated with the mechanism of "thought-action fusion." Our study aimed to elucidate the association of the altered functional coupling of the CSTC nodes (and precuneus), the OCD symptoms, and interference control/cognitive flexibility. Methods: In a group of 36 (17 medicated and 19 drug-free) OCD patients and matched healthy volunteers, we tested functional connectivity (FC) within the constituents of the dorsolateral prefrontal cortex "executive" CSTC, the orbitofrontal cortex/anterior cingulate "affective" CSTC, and precuneus. The functional connections showing the strongest effects were subsequently entered as explanatory variables to multiple regression analyses to identify possible associations between observed alterations of functional coupling and cognitive (Stroop test) and clinical measures (obsessions, compulsions, and anxiety level). Results: We observed increased FC (FWE p < 0.05 corr.) between CSTC seeds and regions of the parieto-occipital cortex, and between the precuneus and the angular gyrus and dorsolateral prefrontal cortex. Decreased FC was observed within the CSTC loop (caudate nucleus and thalamus) and between the anterior cingulate cortex and the limbic lobe. Linear regression identified a relationship between the altered functional coupling of thalamus with the right somatomotor parietal cortex and the Stroop color-word score. Similar association of thalamus FC has been identified also for obsessions severity. No association was observed for compulsions and anxiety. Conclusions: Our findings demonstrate altered FC in OCD patients with a prevailing increase in FC originating in CSTC regions toward other cortical areas, and a decrease in FC within the constituents of CSTC loops. Moreover, our results support the role of Fajnerova et al. Altered Rest-FC and Cognitive Interference in OCD precuneus in OCD. The association of the cognitive and clinical symptoms with the FC between the thalamus and somatomotor cortex indicates that cognitive flexibility and inhibitory control are strongly linked and both mechanisms might contribute to the symptomatology of OCD.

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Section: Fc Alterations In the Ocd Samplesupporting

confidence: 91%

Functional Connectivity Changes in Obsessive–Compulsive Disorder Correspond to Interference Control and Obsessions Severity

et al. 2020

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“…Resting-state fMRI studies have found increased functional connectivity between the caudate, putamen, and OFC, and ACC and parahippocampal areas. [88909293100103104] In addition, the occipital cortex,[95100] cerebellum,[95100] and thalamic[90] connectivity with the striatum has been found to be increased. Decreased functional connectivity has been found within the OFC,[95] cerebellum,[94] and occipital areas.…”

Section: Functional Imagingmentioning

confidence: 99%

“…[94] Decreased functional connectivity has also been found between the dorsal striatum and lateral PFC,[88] ventral striatum and midbrain,[88] and posterior temporal region. [9094] Symptom severity has been positively associated with connectivity in the OFC,[92100] ACC,[104] putamen,[9295] cerebellar region,[95] and lower dorsomedial PFC (DMPFC) intrasystem connectivity and the connectivity of DMPFC with striatal and cingulate areas. [96]…”

Section: Functional Imagingmentioning

confidence: 99%

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Hazari

Narayanaswamy

Venkatasubramanian

2019

Indian J Psychiatry

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Obsessive compulsive disorder (OCD) is a common psychiatric illness and significant research has been ongoing to understand its neurobiological basis. Neuroimaging studies right from the 1980s have revealed significant differences between OCD patients and healthy controls. Initial imaging findings showing hyperactivity in the prefrontal cortex (mainly orbitofrontal cortex), anterior cingulate cortex and caudate nucleus led to the postulation of the cortico-striato-thalamo-cortical (CSTC) model for the neurobiology of OCD. However, in the last two decades emerging evidence suggests the involvement of widespread associative networks, including regions of the parietal cortex, limbic areas (including amygdala) and cerebellum. This narrative review discusses findings from structural [Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging(DTI)], functional [(functional MRI (fMRI), Single photon emission computed tomography (SPECT), Positron emission tomography (PET), functional near-infrared spectroscopy (fNIRS)], combined structural and functional imaging studies and meta-analyses. Subsequently, we collate these findings to describe the neurobiology of OCD including CSTC circuit, limbic system, parietal cortex, cerebellum, default mode network and salience network. In future, neuroimaging may emerge as a valuable tool for personalised medicine in OCD treatment.

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“…35 Involvement of the caudate has been has also been identified in psychiatric disorders such as schizophrenia, 36 depression, 37 and obsessive-compulsive disorders. 38 PERSPECTIVE The cognitive and emotional consequences of caudate lesions associated with widespread hypometabolism in the prefrontal cortex and, as illustrated in patient 2, the contralateral cerebellum emphasizes the concept of network disorder as a cause of cognitive and behavioral manifestations of vascular, neurodegenerative, and psychiatric disorders. Thus, lesions of the striatum, as well as those involving the thalamus 23 or the cerebellum, 39 may produce the same spectrum of cognitive and affective syndromes as those associated with disorders affecting different portions of the prefrontal cortex.…”

Section: Clinical Correlationsmentioning

confidence: 99%

Caudate nucleus as a component of networks controlling behavior

et al. 2017

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Intrinsic functional connectivity alteration of dorsal and rostral anterior cingulate cortex in obsessive-compulsive disorder: A resting fMRI study

Cited by 17 publications

References 20 publications

Functional Connectivity Changes in Obsessive–Compulsive Disorder Correspond to Interference Control and Obsessions Severity

Functional Connectivity Changes in Obsessive–Compulsive Disorder Correspond to Interference Control and Obsessions Severity

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Caudate nucleus as a component of networks controlling behavior

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