Intravoxel incoherent motion parameters in the evaluation of chronic hepatitis B virus-induced hepatic injury: fibrosis and capillarity changes

Gülbay, Mutlu; Cılız, Deniz; Çelikbaş, Aysel Kocagül; Ocalan, Devrim Tuba; Sayın, Bige; Özbay, Bahadır Orkun; Alp, Emre

doi:10.1007/s00261-020-02430-9

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…However, this result is contrary to the results reported by Gulbay M et al. that D * is statistically correlated with MVD ( r = 0.415) ( 29 ). The reasons may be related to the following factors: Firstly, D* has poor repeatability; Secondly, the liver is a double blood supply organ with complex microcirculation perfusion characteristics; Thirdly, a large number of immature neovascularization have high permeability and extensive abnormal pathways in VX2 liver tumors.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging

et al. 2022

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Background and purposeIt is crucial to evaluate the efficacy, recurrence, and metastasis of liver tumors after clinical treatment. This study aimed to investigate the value of Introvoxel Incoherent Motion (IVIM) imaging in the evaluation of rabbit VX2 liver tumors treated with Transcatheter Arterial Embolization (TAE) combined with apatinib.MethodsTwenty rabbit VX2 liver tumor models were established and randomly divided into either the experimental group (n=15) or the control group (n=5). The experimental group was treated with TAE combined with oral apatinib after successful tumor inoculation, while no treatment was administered following inoculation in the control group. IVIM sequence scan was performed in the experimental group before treatment, at 7 and 14 days after treatment. All rabbits were sacrificed after the last scan of the experimental group. Marginal tissues from the tumors of both groups were excised for immunohistochemical analysis to observe and compare the expression of microvessel density (MVD). The alterations of IVIM-related parameters of tumor tissues in the experimental group, including Apparent Diffusion Coefficient (ADC), True Diffusion Coefficient (D), Pseudodiffusion Coefficient (D*), and Perfusion Fraction (f) were compared at different periods, and the correlation between these parameters and MVD was analyzed.ResultsAfter treatment, ADC and D values significantly increased, whereas D* and f values both decreased, with statistically significant differences.(P<0.05). The average tumor MVD of the experimental group after TAE combined with apatinib ((33.750 ± 6.743) bars/high power field (HPF)) was significantly lower than that in the control group ((64.200 ± 10.164) bars/HPF)). Moreover, D and f were positively correlated with tumor MVD in the experimental group (r=0.741 for D and r=0.668 for f, P<0.05). However, there was no significant correlation between ADC and D* values of the experimental group and tumor MVD (r=0.252 for ADC and r=0.198 for D*, P>0.05).ConclusionIVIM imaging can be employed to evaluate the efficacy of TAE combined with apatinib in rabbit VX2 liver tumors. Alterations in D and f values were closely related to the MVD of liver tumor tissues.

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Section: Discussioncontrasting

confidence: 99%

Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging

et al. 2022

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“…ADC and D parameters mainly reflect water molecular diffusion in the extracellular space rather than the intracellular space, 5,22 so it could be inferred that while cytotoxic edema appearing as cellular swelling progresses to be significant during the moderate necrosis period, the effect of vasogenic edema occurs earlier and continuously. In addition, as the values of D* and f derived from IVIM showed no potential in the assessment of hepatotoxicity changes, according to the intrinsic properties 11,22 that the value of D* and f mainly reflecting the microcapilary perfusion in the capillaries, the relative stability in D* and f among groups suggested that overdosing APAP might not cause a significant change in microcirculation perfusion.…”

Section: Discussionmentioning

confidence: 98%

“…9, 10 Yang et al 7 found that the reduction rate of T1 relaxation time on hepatobiliary phase (HBP) strongly correlated with the severity of oxaliplatin-induced liver injury. In addition, intravoxel incoherent motion (IVIM) has been used to assess liver injury caused by hepatitis B virus, 11 chemotherapy, 12 or intestinal ischemia-reperfusion. 13 Both studies showed that diffusion or perfusion parameters had potential in evaluating the severity of liver injury.…”

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confidence: 99%

Noninvasive Assessment of APAP (N‐acetyl‐p‐aminophenol)‐Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model

Chen

Zhao

et al. 2022

Magnetic Resonance Imaging

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Background Early detection and accurate assessment of N‐acetyl‐p‐aminophenol (APAP)‐induced hepatotoxicity can prevent further aggravation of liver injury and reduce the incidence of liver failure. Purpose To evaluate the potential of multiple MRI parameters for assessing APAP‐induced hepatotoxicity in an experimental rat model. Study Type Prospective. Animal Model Twenty‐one APAP‐treated rats and 12 control rats. Field Strength/Sequence A 3 T, T1 mapping, Gd‐EOB‐DTPA‐enhanced MRI, and intravoxel incoherent motion (IVIM). Assessment The severity of histological changes was assessed by a liver pathologist. Rat livers were pathologically classified into three groups: normal (n = 12), mild necrosis (n = 13), and moderate necrosis (n = 8). T1 relaxation time (T1) and diffusion parameters were measured. The reduction rate of T1 (ΔT1%) at different time points, the maximum value of ΔT1%, time period to the maximum value of ΔT1%, and time period from ΔT1max (%) to 2/3 value of ΔT1max (%) (ΔT1‐T2/3) were calculated. Transporters activities like organic anion‐transporting polypeptide 1 (oatp1) and multidrug resistance‐associated protein 2 (mrp2) were compared among different necrotic groups. Statistical Tests ANOVA/Kruskal–Wallis. Pearson/Spearman correlation. P < 0.05 was considered statistical significance. Results T1 Precontrast and ΔT1‐T2/3 were strongly correlated with the severity of necrosis (r = 0.9094; r = 0.7978, respectively) and showed significant differences between the two groups. The apparent diffusion coefficient (ADC) and tissue diffusivity (D) values were significantly lower in the moderate necrosis group than in the normal and mild necrosis groups. The oatp1 activity of the necrosis groups was significantly reduced compared to that of the normal group, but the differences between normal and mild (P = 0.21), normal and moderate group (P = 0.56) were not significant. Meanwhile, enlargement of bile canaliculi and sparse microvilli was observed in the necrotic groups. Conclusion MRI parameters such as precontrast T1 and ΔT1‐T2/3 had promising potential in assessing the severity of early‐stage hepatotoxicity in an APAP overdose rat model. Evidence Level 1 Technical Efficacy Stage 1

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Magnetic Resonance imaging analysis of liver fibrosis and inflammation: overwhelming gray zones restrict clinical use

2020

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Intravoxel incoherent motion parameters in the evaluation of chronic hepatitis B virus-induced hepatic injury: fibrosis and capillarity changes

Cited by 6 publications

References 34 publications

Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging

Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging

Noninvasive Assessment of APAP (N‐acetyl‐p‐aminophenol)‐Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model

Magnetic Resonance imaging analysis of liver fibrosis and inflammation: overwhelming gray zones restrict clinical use

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