Intravitreale Low-Dose-Gentamicininjektion zur Behandlung
                    ERU-erkrankter Pferde

Kleinpeter, A.; Göpfert, Agnes; Köhler, Elisa; Brehm, Walter

doi:10.1055/a-0816-7156

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…Similar considerations hold true for the low-dose intravitreal gentamicin (4 mg) injection, which successfully controlled different stages of inflammation in horses with recurrent or persistent uveitis 38. In a second case series,39 potential antibiotic properties addressing leptospiral-induced ERU have been suggested. Recent human research proved high susceptibility of B. afzelii to gentamicin 40.…”

Section: Discussionmentioning

confidence: 88%

Arthritis, panuveitis and hyperaesthesia associated with Borrelia afzelii infection in a warmblood gelding

Sommerauer

Blohm

Spergser

et al. 2019

Vet Record Case Reports

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A 13-year-old warmblood gelding presented with a history of lameness, muscle atrophy and weight loss of 3 months. The horse demonstrated extensive hyperaesthesia over the left dorsal trunk, marked effusion of several joints, laryngitis and a dampened mental attitude. Synovial fluid analysis revealed arthritis of the left tarsocrural joint, being PCR-positive for Borreliaafzelii DNA. Subsequently, mild anterior uveitis of the right and severe panuveitis of the left eye with B. afzelii PCR-positive aqueous and vitreous humour, respectively, were diagnosed. Treatment included arthroscopy of the left tarsocrural joint, oral doxycycline administration for 6 weeks, ophthalmic and systemic anti-inflammatory therapy and left intravitreal preservative-free gentamicin (4 mg) injection. After initial improvement, the gelding’s clinical signs deteriorated resulting in peracute recumbency and sudden death 12 months later. Lyme borreliosis should be considered as differential diagnosis in complex cases of equine lameness, particularly when accompanied by hyperaesthesia and bilateral uveitis.

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Section: Discussionmentioning

confidence: 88%

Arthritis, panuveitis and hyperaesthesia associated with Borrelia afzelii infection in a warmblood gelding

Sommerauer

Blohm

Spergser

et al. 2019

Vet Record Case Reports

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“…In recent years, an injection of 4-6 mg gentamicin (which is really gentamicin sulfate, but is dosed according to the gentamicin content), preferably a preservative-free solution [292], into the vitreous cavity has been described as a less demanding therapeutic method for ERU [292][293][294][295]. This does not require specialized instruments and equipment, and performing the injection is easier and less expensive than vitrectomy [296].…”

Section: Chronic Course Of Uveitismentioning

confidence: 99%

Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis

2022

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Uveitis is a sight-threatening eye disease in equids known worldwide that leads to considerable pain and suffering. By far the most common type of uveitis in Germany and neighboring countries is classical equine recurrent uveitis (ERU), which is caused by chronic intraocular leptospiral infection and is the main cause of infectious uveitis in horses. Other infectious causes are extremely rare and are usually clinically distinguishable from ERU. ERU can be treated very effectively by vitreous cavity lavage (vitrectomy). For proper indications of this demanding surgery, it is necessary to differentiate ERU from other types of uveitis in which vitrectomy is not helpful. This can be conducted on the basis of anamnesis in combination with ophthalmologic findings and by aqueous humor examination. During vitrectomy, vitreous material is obtained. These vitreous samples have historically been used for numerous etiologic studies. In this way, a chronic intraocular leptospiral infection has been shown to be the cause of typical ERU and, among other findings, ERU has also been recognized as a biofilm infection, providing new insights into the pathogenesis of ERU and explaining some thus far unexplainable phenomena of ERU. ERU may not only have transmissible aspects to some types of uveitis in humans, but may also serve as a model for a spontaneously occurring biofilm infection. Vitreous material obtained during therapeutically indicated vitrectomy can be used for further studies on in vivo biofilm formation, biofilm composition and possible therapeutic approaches.

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“…Seventeen of the 18 eyes (94.4%) treated with IVGI remained free from recurrences (follow-up time of 62-781 days) (Pinard, 2005). Kleinpeter et al (2014) and Kleinpeter et al (2019) presented data from 60 eyes treated with IVGI under general anaesthesia (followup time of 2-96 months). Ninety-three per cent (56/60) of the eyes did not develop recurrences, but 11/60 eyes developed a cataract following IVGI (Kleinpeter et al, 2014(Kleinpeter et al, , 2019.…”

Section: Low-dose Intravitreal Gentamicin Injections (Ivgi)mentioning

confidence: 99%

“…Kleinpeter et al (2014) and Kleinpeter et al (2019) presented data from 60 eyes treated with IVGI under general anaesthesia (followup time of 2-96 months). Ninety-three per cent (56/60) of the eyes did not develop recurrences, but 11/60 eyes developed a cataract following IVGI (Kleinpeter et al, 2014(Kleinpeter et al, , 2019. McMullen (2015) presented the first case series of horses treated via IVGI under standing sedation (Figure 4).…”

Section: Low-dose Intravitreal Gentamicin Injections (Ivgi)mentioning

confidence: 99%

“…Cataract formation was seen in 8.5% and retinal degeneration in 5.1% of the cases (Fischer et al, 2019). Kleinpeter et al (2019) concluded that IVGI has a low complication rate and serves as a viable alternative to the PPV, a surgery widely utilised throughout Germany. Launois et al (2019) presented a case series of 71 horses that were treated with 6 mg IVGI.…”

Section: Intravitreal and Suprachoroidal Injectionsmentioning

confidence: 99%

See 1 more Smart Citation

Equine recurrent uveitis—A review

Fischer

Brehm

Reese³

et al. 2022

Equine Veterinary Education

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According to recent studies from Canada and the south-eastern United States, approximately one third of the horses evaluated were bilaterally blind at their first ophthalmologic examination (Gerding & Gilger, 2016;Sandmeyer et al., 2017). These results demonstrate the need for early referral in cases diagnosed with ERU, even if the recognisable signs are mild. Blindness may lead to a horse being retired early, or even subjected to euthanasia. Both situations are coupled with emotional, as well as financial concerns for their owners (Abrams & Brooks, 1990;Gerding & Gilger, 2016;Rebhun, 1979).Topical and/or systemic medical (immunosuppressive and antiinflammatory) therapy are the foundation of any ERU treatment.However, medical therapy alone insufficiently controls or suppresses acute inflammation or prevents recurrent intraocular inflammation. In such instances, surgical intervention may be indicated (Allbaugh, 2017;Spiess, 2010). Pars plana vitrectomy (PPV) and suprachoroidal cyclosporine implant (SCI) placement are both recognised and effective surgical treatment options for ERU (Frühauf

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Intravitreale Low-Dose-Gentamicininjektion zur Behandlung ERU-erkrankter Pferde

Cited by 8 publications

References 24 publications

Arthritis, panuveitis and hyperaesthesia associated with Borrelia afzelii infection in a warmblood gelding

Arthritis, panuveitis and hyperaesthesia associated with Borrelia afzelii infection in a warmblood gelding

Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis

Equine recurrent uveitis—A review

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