Intravitreal Injection-Induced Migraine Headaches

Lerebours, Valerie; Nguyen, Thanh-Giao; Sarup, Vimal; Rossi, Fabian; Shaikh, Saad

doi:10.7759/cureus.561

Cited by 1 publication

(1 citation statement)

References 3 publications

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“… 5 23 However, headache reported in this study has been previously associated with an elevated post-injection IOP 37 and found in individuals who experienced episodic migraines following anti-VEGF treatment. 38 Practitioners referred to reviewing patients’ medical records to determine history of allergies, ocular infections and IOP to treat patients accordingly.…”

Section: Discussionmentioning

confidence: 99%

Pain related to intravitreal injections for age-related macular degeneration: a qualitative study of the perspectives of patients and practitioners

et al. 2023

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ObjectivesOcular pain is a commonly reported finding in the intravitreal injection procedure, but post-injection experiences and patient adherence to treatment remain underexplored. We therefore aimed to identify key variations in the intravitreal injection procedure that may influence pain, and to gain insights into the post-injection experience and treatment adherence from the perspective of patients and practitioners.DesignQualitative semistructured interview study using reflexive thematic analysis of transcripts.SettingHospital Eye Clinic in Wales, UK. Interviews were conducted between May and September 2019.ParticipantsPurposive sample of patients aged ≥50 years with neovascular age-related macular degeneration and no other retinal pathology who had received at least six intravitreal injections, and practitioners including ophthalmologists, registered nurses and optometrists who performed intravitreal injections at the research site.ResultsData saturation was reached with 21 interviews: 14 patients and 7 practitioners. Three main themes were identified from the analysis: fear of losing eyesight and treatment anxiety influence patient adherence to treatment, variability in pain experience during treatment, and post-injection experience and impact on patient recovery. To reassure patients feeling apprehensive about the injections, practitioners promoted safety and trust, and used techniques to manage anxiety. Key variations that may influence pain identified were application of antiseptic or anaesthetic, injecting methods and communication. During injection, patients reported a dull-aching and sharp pain, contrary to practitioners’ perspective of feeling a ‘pressure’. Patients described prolonged soreness and irritation of up to 36 hours post-injection affecting their sleep and recovery.ConclusionEstablishing rapport supported patients to recognise the necessity of ongoing treatment to prevent sight loss; however, inadequate pain management led to undesirable outcomes. Practitioners should use pain assessment tools during and immediately after injection and provide ongoing consistent information to help patients manage pain at home.

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Section: Discussionmentioning

confidence: 99%