Intravitreal bevacizumab in pigmented rabbit eyes: histological analysis 90 days after injection

Arraes, João Carlos Diniz; Tedesco, Roberto; Arraes, Tatiana Azevedo; Silva, Elilson Batista da; Ventura, Alexandre A.C.M.; Ávila, Marcos Pereira de

doi:10.1590/s0004-27492009000500011

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Detachment of the neuroretina from RPE was found on the control and injected eye to the same degree, and was consistent with tissue processing artefacts [38]. …”

Section: Methodssupporting

confidence: 56%

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

Giannaccini

Giannini

Calatayud

et al. 2014

IJMS

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One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species.

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“…Detachment of the neuroretina from RPE was found on the control and injected eye to the same degree, and was consistent with tissue processing artefacts [38]. …”

Section: Methodssupporting

confidence: 56%

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

Giannaccini

Giannini

Calatayud

et al. 2014

IJMS

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“…(Inan et al, 2007). Por outro lado, Arraes et al (2009) não observaram alterações retinianas à microscopia óptica 90 dias após a administração IV de bevacizumabe, também em retina de coelhos.…”

Section: Espessura Retiniana E Spectral Domain Optical Coherence Tomounclassified

Papel do VEGF nas alterações retinianas provocadas pela hipóxia normobárica em coelhos

Castro¹

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Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats

et al. 2012

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Intravitreal bevacizumab in pigmented rabbit eyes: histological analysis 90 days after injection

Cited by 5 publications

References 21 publications

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

Papel do VEGF nas alterações retinianas provocadas pela hipóxia normobárica em coelhos

Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats

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