Intravitreal bevacizumab for posttraumatic choroidal neovascularization in a child

Piermarocchi, Stefano; Benetti, Elisa; Fracasso, Gianfranco

doi:10.1016/j.jaapos.2011.02.008

Cited by 5 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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“…A secondary CNV developing after ocular contusion trauma may be related to a rupture of Bruch's membrane, inflammatory response, and abnormal production of vascular endothelial growth factor. Many reports on the treatment of secondary CNV following choroidal rupture have been published [12, 13, 14, 15], and the present case experienced an improvement following an intravitreal bevacizumab injection.…”

Section: Discussionmentioning

confidence: 55%

A Case of Expansion of Traumatic Choroidal Rupture with Delayed-Developed Outer Retinal Changes

Moon

Kim

2013

Case Rep Ophthalmol

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Background: This study aims to report the expansion of a choroidal rupture site caused by blunt ocular trauma using scanning laser ophthalmoscope-optical coherence tomography. Case Report: The clinical course of a 15-year-old girl with a traumatic ocular injury after being hit in the eye by an elbow was evaluated. Upon the first examination, the best-corrected visual acuity was 16/20. The findings were subretinal pigment epithelial hemorrhage and vertical choroidal rupture. Three weeks after the trauma, the patient's visual acuity was reduced to counting fingers at 30 cm. On fundus examination and fluorescein angiography subretinal pigment epithelial hemorrhage decreased, while the choroidal rupture expanded; on optical coherence tomography outer retinal changes in the adjacent area were detected. Discussion: This study reveals that the delayed expansion of a choroidal rupture site and the delayed change of the adjacent outer retina improved.

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Section: Discussionmentioning

confidence: 55%

A Case of Expansion of Traumatic Choroidal Rupture with Delayed-Developed Outer Retinal Changes

Moon

Kim

2013

Case Rep Ophthalmol

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“…51 In subjects sustaining trauma, CNV has been reported in the presence of choroidal ruptures during the healing phase. [52][53][54][55][56] However, in the present study, we had one case of traumatic CNV in the absence of choroidal rupture. Other causes of CNV in children and adolescents are retinal dystrophies, including Stargardt disease, 57 choroideremia, 58 North Carolina macular dystrophy, 59 and other macular dystrophies.…”

Section: Choroidal Neovascularization In Children and Adolescents P Rmentioning

confidence: 76%

Choroidal neovascularization in 36 eyes of children and adolescents

Rishi

Gupta

Rishi

et al. 2013

Eye

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Purpose To describe the clinical features and outcomes among eyes with choroidal neovascularization (CNV) in children and adolescents. Methods A total of 36 eyes of 27 patients o18 years of age diagnosed with CNV between January 1978 and December 2008 were retrospectively reviewed. CNV was clinically diagnosed in all patients and its presence was confirmed by fundus fluorescein angiography (FFA). A total of 19 eyes underwent treatment. Anatomical outcome was evaluated as regressed/ persistent/recurrent CNV. Snellen's values for best corrected visual acuity (BCVA) were converted to logMAR for statistical calculations. Results Of the 27 patients, 17 (63%) were male. Nine (33.3%) of the 27 patients had bilateral CNV. At presentation, CNV was active in 22 (61.1%) eyes and regressed in 14 (28.9%) eyes. All active CNV cases were 'classic' type, with the majority (80.5%) being subfoveal. The mean greatest linear dimension (GLD) was 3.16 ± 1.94 mm (range, 0.9-10.15). The most common cause (41.7%) was post-inflammatory. The mean duration to regression in treated eyes was 103.53 days (15 eyes). Recurrence was noted in three (8.3%) eyes. The mean duration to first recurrence was 260 days (range, 90-390), and the mean follow-up duration was 779.53 ± 988.00 days. Conclusion CNV remains a cause of significant visual decline in children and adolescents. Male predominance, postinflammatory etiology, bilateral affection, and subfoveal location are noteworthy, with a high regression rate in response to treatment. Re-treatment is required in a limited number of cases.

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“…At 3-month follow-up, there were no complications, and vision and OCT both remained stable. 48 Since then, a number of case reports have been published on the successful use of bevacizumab for CNVM in a number of pediatric diseases including high myopia, 49,50 trauma, 51 osteogenesis imperfecta, 52 idiopathic intracranial hypertension, 53 toxoplasmosis, 54,55 choroidal osteoma, 56 Best disease, 57,58 cat scratch disease, 59 optic nerve and retinochoroidal coloboma, 60 and hamartoma of the retina and retinal pigment epithelium (RPE). 55 In the first large series, Kozak et al 61 reported on a retrospective, multicenter interventional case series of 39 children aged 3-17 years with CNVM due to various etiologies treated with anti-VEGF agents (34 bevacizumab or 5 ranibizumab).…”

Section: Cnvmsmentioning

confidence: 99%

The use of bevacizumab in pediatric retinal and choroidal disease: A review

Belin

Lee

Greaves

et al. 2019

European Journal of Ophthalmology

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The use of intravitreal bevacizumab in pediatric retinal and uveitic disease has become more widespread over the past decade. This article serves to outline the rationale underlying the use of intravitreal bevacizumab, and which disease entities it should be appropriately thought of as a primary or solo therapy, as opposed to an adjuvant one. Also presented is the relevant literature regarding each of these retinopathies.

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Intravitreal bevacizumab for posttraumatic choroidal neovascularization in a child

Cited by 5 publications

References 10 publications

A Case of Expansion of Traumatic Choroidal Rupture with Delayed-Developed Outer Retinal Changes

A Case of Expansion of Traumatic Choroidal Rupture with Delayed-Developed Outer Retinal Changes

Choroidal neovascularization in 36 eyes of children and adolescents

The use of bevacizumab in pediatric retinal and choroidal disease: A review

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