The use of bevacizumab in pediatric retinal and choroidal disease: A review

Belin, Peter J.; Lee, Andrew C.; Greaves, Giovanni; Kosoy, Jennifer; Lieberman, Ronni M.

doi:10.1177/1120672119827773

Cited by 7 publications

(5 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coats disease represents a broad clinical spectrum of retinal vasculopathy, predominantly in children, and demonstrating telangiectasia, exudation, retinal detachment, and occasionally neovascular glaucoma or phthisis bulbi. [123456789101112131415161718] The management of Coats disease begins with documentation of the extent of vasculopathy using clinical examination and imaging, particularly with fluorescein angiography. When extensive exudation or retinal detachment is present, Coats disease can simulate malignant retinoblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, we have noted more sophisticated treatment of Coats disease with vitreoretinal or subretinal/external drainage surgery, laser photocoagulation, and periocular and/or intravitreal medications leading to a reduction in the need for enucleation, especially in advanced-stage Coats disease. [9101112131415161718] Herein, we provide a comprehensive overview of our 45-year experience with Coats disease diagnosis and management. We compare, by decade, the clinical and imaging features, management, and outcomes in 351 consecutive cases based on Coats disease classification.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center

Shields

Udyaver

Dalvin

et al. 2019

Indian J Ophthalmol

View full text Add to dashboard Cite

Purpose: To assess features and outcomes of Coats disease over 5-decades. Methods: Retrospective review of Coats disease patients at a single center. Features and outcomes were compared based on decade of presentation. Results: There were 351 patients with Coats disease. The presenting median age (6 years), male sex (84%), and unilaterality (100%) did not change per decade. Coats disease classification did not change per decade with Stage 1 (1%), Stage 2 (21%), Stage 3 (68%), Stage 4 (6%), and Stage 5 (1%). Clinical features that changed per decade (1970s vs. 1980s vs. 1990s vs. 2000s vs. 2010s) included 1980s features of more eyes with exudation in all 4 quadrants (22% vs. 58% vs. 44% vs. 33% vs. 27, P = 0.01) and total exudative retinal detachment (33% vs. 53% vs. 39% vs. 27% vs. 21%, P < 0.001). Imaging features that changed per decade included 2010s greater fluorescein angiographic extent of retinal non-perfusion in mean clock hours (4 vs. 4 vs. 3 vs. 5 vs. 6, P = 0.003), and 1980s greater mean height of retinal detachment ultrasonographically (5 vs. 12 vs. 5 vs. 5 vs. 4 mm, P < 0.001). Treatment features that changed per decade included 1980s greater primary enucleation (11% vs. 16% vs. 3% vs. 4% vs. 1%, P = 0.001), and 2010s greater use of laser photocoagulation (55% vs. 33% vs. 38% vs. 40% vs. 72%, P < 0.001), sub-Tenon corticosteroid (0% vs. 4% vs. 5% vs. 8% vs. 29%, P < 0.001), and intravitreal anti-VEGF) (0% vs. 4% vs. 2% vs. 13% vs. 18%, P = 0.003). Outcomes that changed per decade included 2010s findings of more complete resolution of subretinal fluid (64% vs. 59% vs. 38% vs. 58% vs. 72%, P = 0.01) and less need for primary/secondary enucleation (17% vs. 27% vs. 14% vs. 13% vs. 6%, P = 0.04). Conclusion: Eyes with Coats disease in the 1980s demonstrated more advanced findings, often requiring enucleation. Over the decades, greater use of laser photocoagulation and injections has led to improved disease resolution with greater globe salvage.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center

Shields

Udyaver

Dalvin

et al. 2019

Indian J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…It blocks the interaction between VEGF-A and VEGFR, primarily VEGFR-1 and VEGFR-2, on the surface of endothelial cells. Bevacizumab is currently approved for the treatment of recurrent, persistent or metastatic cervical cancer, metastatic colorectal cancer, glioblastoma, nonsquamous non-small cell lung cancer (NonSq-NSCLC), ovarian cancer, fallopian tube or primary peritoneal cancer and metastatic renal cell carcinoma (RCC) [ 79 , 80 , 81 , 82 , 83 ]. Similarly, ramucirumab is a monoclonal antibody inhibitor targeting VEGFR2 that is approved for the treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma, NSCLC, metastatic colorectal cancer, and hepatocellular carcinoma (HCC) [ 84 , 85 , 86 , 87 ].…”

Section: Clinical Evidencementioning

confidence: 99%

Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer

et al. 2020

View full text Add to dashboard Cite

Although immunotherapy has led to durable responses in diverse cancers, unfortunately, there has been limited efficacy and clinical response rates due to primary or acquired resistance to immunotherapy. To maximize the potential of immunotherapy, combination therapy with antiangiogenic drugs seems to be promising. Some phase III trials showed superiority for survival with the combination of immunotherapy and antiangiogenic therapy. In this study, we describe a synergistic mechanism of immunotherapy and antiangiogenic therapy and summarize current clinical trials of these combinations.

show abstract

“…Second, as the retina matures, the increased metabolic activity overwhelms the oxygenation supply from the existing vascular supply resulting in retinal ischemia. This in turn results in increased production of VEGF leading to abnormal neovascular proliferation (1,2).…”

Section: Introductionmentioning

confidence: 99%

Aggressive Posterior Retinopathy of Prematurity: Long-Term Outcomes Following Intravitreal Bevacizumab

et al. 2022

View full text Add to dashboard Cite

PurposeThe purpose of this study is to review the neonatal and early childhood course of children who were treated with intravitreal bevacizumab for APROP and identify any long term limitations these children face years after treatment.MethodsThis retrospective consecutive case series reviewed both ophthalmologic and pediatric medical records to determine ocular and neurologic function following treatment with a single injection of intravitreal bevacizumab (IVB) for APROP. Patient records were reviewed to identify the gestational age, average birth weight, gender, post-menstrual age (PMA) at the time of injection, regression status, rescue therapy events, final visual acuity, final refraction, ophthalmologic diagnoses and complications, neurologic diagnoses, and duration of follow up.ResultsThe study included 43 eyes from 13 male and 9 female children. The average gestational age was 24 weeks and average birth weight was 625.2 grams. The average follow-up was 4.08 years (range: 1.85–7.36 years). The average PMA at time of bevacizumab injection was 35.59 weeks. Thirty-five eyes eventually received laser photocoagulation at an average PMA of 53.17 weeks. All eyes in this study demonstrated regression without progression to retinal detachment. At last follow up, 67% (29/43) of eyes were able to discern letters or shapes, with an average visual acuity of 20/37. 16 (72%) children were diagnosed with perinatal neurological disorders. 59% (n = 13) developed chronic neurological impairment, 77% (n = 10) of whom developed neurodevelopmental delay. Several infants were diagnosed with endocrine disease or genetic syndromes.ConclusionsExtreme prematurity is associated with significant morbidity. Nearly all infants (92%) who developed chronic neurologic disease were diagnosed with neurologic disease during the perinatal period. Intravitreal bevacizumab, often with adjuvant photocoagulation, led to regression without detachment in 100% of eyes, with most verbal children retaining functional vision.

show abstract

The use of bevacizumab in pediatric retinal and choroidal disease: A review

Cited by 7 publications

References 83 publications

Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center

Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center

Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer

Aggressive Posterior Retinopathy of Prematurity: Long-Term Outcomes Following Intravitreal Bevacizumab

Contact Info

Product

Resources

About