Abstract:Purpose Evaluate efficacy and safety of IVT‐AFL for treatment of macular edema due to CRVO.
Methods Patients randomized to IVT‐AFL 2‐mg (IVT‐AFL 2q4) or sham monthly for 24 weeks. COPERNICUS: all patients received IVT‐AFL PRN from week 24‐100 (IVT‐AFL 2q4PRN and shamIVT‐AFL PRN). GALILEO: IVT‐AFL PRN was administered to IVT‐AFL group from week 24‐76 and sham group from week 52‐76.
Results Proportion of IVT‐AFL 2q4PRN and shamIVT‐AFL PRN patients gaining ≥15 letters was 56.1% vs 12.3% and 49.1% vs 23.3%, re… Show more
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