Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease

Abstract

We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal neovascularization following retinal photocoagulation, periocular triamcinolone, and intravitreal ranibizumab injection. Retinal neovascularization initially regressed, but recurred after 5 months along with macular edema. Two more intravitreal aflibercept injections were given, and retinal neovascularization with macular edema regressed. Her vision improved to 20/25 and remained stable after 43 months. Case 2 was a 27-year-old female. Intravitreal aflibercept was administered after persistent retinal neovascularization and macular edema following periocular triamcinolone injection. The macular edema initially subsided but recurred after 3 months. Intravitreal aflibercept injections were then administered once every three months to maintain her vision 20/20. The patient has been followed up for 28 months. Intravitreal aflibercept was effective as a rescue therapy in the treatment of Eales disease to regress retinal neovascularization, though repeated injections were necessary in cases of recurrence.

Eales Disease

“…Makülada ödem ve retinada neovaskülarizasyon gelişmiş olgularda intravitreal anti-VEGF enjeksiyonlarının etkili olduğu gösterilmiştir. [34][35][36] Planlanan vitrektomi öncesi intravitreal bevacizumab enjeksiyonu uygulanan 14 hastanın incelendiği bir çalışmada, 4 hastada sekonder regmatojen retina dekolmanı geliştiği bildirilmiştir. Dekolman oranının bu kadar yüksek olması, bu hastalarda genellikle vitreusun henüz likefiye olmamasına ve posterior vitreus dekolmanı gelişmemiş olmasına bağlı olabileceği öne sürülmüştür.…”