Intravital video-capillaroscopy for the study of the microcirculation in psoriasis

Bull, R.H.; Bates, DO; Mortimer, Peter

doi:10.1111/j.1365-2133.1992.tb11815.x

Cited by 77 publications

(56 citation statements)

References 16 publications

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“…Our preliminary observations confirm, in the lesional skin, the presence of many uniformly arranged tortuous and dilated loops, according to previous capillaroscopic studies [5, 15], but, in addition, we found a different pattern of distribution and morphology of capillary loops in perilesional skin. Moreover, we found an increase in capillary density in perilesional skin.…”

Section: Discussionsupporting

confidence: 79%

“…Bacharach-Bules et al [4]consider that elongation of intrapapillary capillaries is not due to angiogenesis; similarly, Bull et al [5]found that the density of capillaries was not increased in the plaque compared to the uninvolved psoriatic skin (at least 2 cm from the edge of a plaque), suggesting expansion of existing vessels and no new vessel formation.…”

Section: Discussionmentioning

confidence: 99%

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Videocapillaroscopic Findings in the Microcirculation of the Psoriatic Plaque

Angelis

Bugatti²,

Medico

et al. 2002

Dermatology

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Background: Videocapillaroscopy (VCP) is a method to study the morphology and dynamics of microcirculation, but information about capillaroscopic features of the psoriatic plaque is limited. Objective: To investigate the distribution, morphology and density of capillaries in lesional and perilesional skin of the psoriatic plaque. Methods: VCP of a well-delimited plaque of the trunk, arms or legs in 15 consecutive patients with untreated, chronic plaque psoriasis was performed. Results: In the lesional skin, capillaries were tortuous and dilated, homogeneously appearing as ‘bushy’. In the perilesional skin, capillary loops seemed to be on a parallel course with respect to the skin surface, with their apex directed towards the marginal zone. The number of capillary loops per area unit was statistically increased in perilesional compared to lesional skin. Conclusion: According to the morphology, distribution and density of capillary loops, two different angiogenetic patterns were found in lesional and perilesional skin.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Videocapillaroscopic Findings in the Microcirculation of the Psoriatic Plaque

Angelis

Bugatti²,

Medico

et al. 2002

Dermatology

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“…However, controversies exist whether the initiating events are primarily epidermal or vascular [1, 10, 12, 14, 15, 16, 17, 18, 19]. The relationship if any between the extent in these two tissue hyperplasias has not been thoroughly studied so far using fractal geometry.…”

Section: Introductionmentioning

confidence: 99%

“…The relationship if any between the extent in these two tissue hyperplasias has not been thoroughly studied so far using fractal geometry. The classical analytical methods used to quantify these changes are based on Euclidean geometry [8, 13, 14, 15, 16, 17, 18, 19]. In some instances, fractal geometry is better suited for assessing structures with irregular shapes because quantitative data in the volume, area and length of such objects vary dramatically as a function of the scale of measurement used [19, 20, 21, 22, 23, 24, 25].…”

Section: Introductionmentioning

confidence: 99%

Vascularity and Fractal Dimension of the Dermo-Epidermal Interface in Guttate and Plaque-Type Psoriasis

Uhoda¹,

Pierard²,

Piérard-Franchimont³

et al. 2005

Dermatology

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Background: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. Objective: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. Method: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. Results: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. Conclusion: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other.

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“…Videocapillaroscopy (VCP) uses an optical fiber probe connected to a microvideotelecamera, and allows morphologic and functional analysis of microcirculation at all cutaneous sites. VCP has been used for analyzing cutaneous microcirculation in skin diseases such as erythematotelangiectatic rosacea [3] and psoriasis [4, 5]. Psoriasis is a chronic inflammatory disease that involves cutaneous vessels, with the presence of elongated and dilated capillaries in the papillary dermis [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Videocapillaroscopy in the Differential Diagnosis between Psoriasis and Seborrheic Dermatitis of the Scalp

et al. 2006

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Background: Videocapillaroscopy (VCP) can be used to explore microcirculatory modifications in skin diseases. Psoriasis shows specific capillary alterations reflecting typical histopathological changes. Objective: To compare capillary morphology, distribution and density in psoriasis and seborrheic dermatitis of the scalp for differential diagnosis. Methods: VCP was performed on histology-confirmed scalp lesions of 30 patients with chronic plaque psoriasis, 30 age- and sex-matched patients with seborrheic dermatitis and 30 healthy subjects. The morphology, mean density per mm² and mean diameter of capillary loops was measured. Results: Scalp psoriasis exhibited homogeneously tortuous and dilated capillaries (bushy pattern), with a 73 ± 17 µm (mean ± standard deviation) diameter of capillary bushes. In contrast, scalp seborrheic dermatitis presented a multiform pattern, with mildly tortuous capillary loops and isolated dilated capillaries, but a substantial preservation of local microangioarchitecture. Mean diameter of capillary bush was significantly lower (27 ± 4 µm; p < 0.001) and similar to that of the scalp of healthy subjects (21 ± 5 µm). Capillary loop density was similar in patients with psoriasis (23 ± 5/mm²) seborrheic dermatitis (24 ± 2/mm²) and healthy scalp skin (24 ± 3/mm²). Conclusion: VCP could be a useful noninvasive approach for differentiating between psoriasis and seborrheic dermatitis, especially when the scalp is the only affected site.

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Intravital video-capillaroscopy for the study of the microcirculation in psoriasis

Cited by 77 publications

References 16 publications

Videocapillaroscopic Findings in the Microcirculation of the Psoriatic Plaque

Videocapillaroscopic Findings in the Microcirculation of the Psoriatic Plaque

Vascularity and Fractal Dimension of the Dermo-Epidermal Interface in Guttate and Plaque-Type Psoriasis

Videocapillaroscopy in the Differential Diagnosis between Psoriasis and Seborrheic Dermatitis of the Scalp

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