Intraventricular hemorrhage in neonates born from 23 to
26 weeks of gestation: Retrospective analysis of risk factors

Szpecht, Dawid; Nowak, Irmina; Kwiatkowska, Paulina; Szymankiewicz, Marta; Gadzinowski, Janusz

doi:10.17219/acem/65311

Cited by 15 publications

(7 citation statements)

References 18 publications

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“…The The incidence of developing IVH was higher among infants who were born with a birth weight of less than 1000 g. Prematurity and low birth weight are amongst some of the well-recognized risk factors for IVH [1,5,[12][13][14]. The severity of IVH in our study population was inversely proportional to gestational age, birth weight, and Apgar scores.…”

Section: Discussionmentioning

confidence: 75%

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

et al. 2023

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Purpose The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like growth factor 1 receptor (IGF-1R G3174A) and the occurrence of IVH in a population of preterm infants. Methods The study includes a population of 105 infants born from 24 + 0 to 32 + 0 weeks of gestation and hospitalized at the Department of Neonatology (III level hospital) of Poznan University of Medical Science. Intraventricular hemorrhage was diagnosed with the use of cranial ultrasound. The classification of intraventricular bleeding was based on the Papile IVH classification. Results The incidence of IVH was higher in infants with lower birth weight, lower APGAR scores, and low birth weight. The study revealed that IVH was approximately two times less likely to occur in infants with the allele G of IGF-1R 3174G > A. Conclusion Identifying susceptible premature infants through genetic analysis could be a potential way to alleviate severe IVH and its subsequent consequences. Further research examining a wider range of relevant gene polymorphisms could help highlight any genetic patterns in this deleterious bleeding complication.

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Section: Discussionmentioning

confidence: 75%

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

et al. 2023

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“…Moreover, in a similar study realized in extreme PNB (GA 23-26 weeks) the principal risk factor was found to be the gestational age, on the other hand, the use of prenatal steroids and reduced use of catecholamines for arterial hypotension were associated as protection factors [7]. Additionally, in a cohort study realized in 135 PNB with weight lower of 1.5 kg it was determined that 33.3% of the population developed IVH and the weight and gestational age were identi ed as risk factors to develop IVH [8].…”

Section: Introductionmentioning

confidence: 66%

Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants

Puerta-Martínez,

López-Garrido,

Guerrero-Nava

et al. 2024

Childs Nerv Syst

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To analyze the association between risk factors and severe intraventricular hemorrhage (Grade II-IV) in PNB under 1500 grams. MethodsMulticenter, retrospective, analytical, case-control, study in PNB under 34 weeks and under 1500 grams admitted to the NICU Case: PNB with severe intraventricular hemorrhage (grade II-IV). Logistic regression analysis was used to adjust for IVH-associated variables and odds ratios (OR). ResultsA total of 90 PNB les were analyzed, 45 cases and 45 controls. The highest risk factors for severe IVH were lower gestational age (OR:1.3, p < 0.001), perinatal asphyxia (OR:12, p < 0.001

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“…Findings are graded on a scale from I to IV [16] and it is estimated that it affects 15-20% of the neonates born <32 weeks [2,[15][16][17].…”

Section: Definitions Of Nbi Intraventricular Hemorrhage (Ivh)mentioning

confidence: 99%

Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates

Metallinou

Karampas

Nyktari

et al. 2021

Bosn J of Basic Med Sci

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Neonatal brain injury is a serious adverse outcome of prematurity. Early detection of high risk premature neonates to develop neonatal brain injury is not currently feasible. The predictive value of many biomarkers has been tested, but none is used currently in clinical practice. The purpose of this study was to determine the levels and predictive value of serum glial fibrillary acidic protein (GFAP) in a prospective longitudinal case-control study during the first three days of life in premature neonates (<34 weeks of gestation) that later developed either intraventricular hemorrhage or periventricular leukomalacia. Each case (n=29) was matched according to birth weight and gestational age to one neonate with normal head ultrasound scans. No significant difference on GFAP levels was observed between the groups. Nevertheless, neonates with brain injury presented more frequently GFAP levels above the lowest detection limit (0.056 ng/ml) and this trend was significantly different during all days. The effectiveness of GFAP as an early biomarker of neonatal brain injury in premature neonates seems to be limited.

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Intraventricular hemorrhage in neonates born from 23 to 26 weeks of gestation: Retrospective analysis of risk factors

Cited by 15 publications

References 18 publications

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants

Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates

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