Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

Abstract

Purpose The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like growth factor 1 receptor (IGF-1R G3174A) and the occurrence of IVH in a population of preterm infants. Methods The study includes a population of 105 infants born from 24 + 0 to 32 + 0 weeks of gestation and hospitalized at the Department of Neonatology (III level hospital) of Poznan University of Medical Science. Intraventricular hemorrhage was diagnosed with the use of cranial ultrasound. The classification of intraventricular bleeding was based on the Papile IVH classification. Results The incidence of IVH was higher in infants with lower birth weight, lower APGAR scores, and low birth weight. The study revealed that IVH was approximately two times less likely to occur in infants with the allele G of IGF-1R 3174G > A. Conclusion Identifying susceptible premature infants through genetic analysis could be a potential way to alleviate severe IVH and its subsequent consequences. Further research examining a wider range of relevant gene polymorphisms could help highlight any genetic patterns in this deleterious bleeding complication.

Hypoxia-Inducible Pathway Polymorphisms and Their Role in the Complications of Prematurity

“…As shown in our previous study, in a smaller group of cases in which any stage of IVH (grade I-IV in ultrasound classification) was present in 44% of infants, a stronger influence of genetic factors can be found for severe IVH (grade II-IV), occurring in approximately 60% of cases. Stage I (42% of IVH cases), defined as unilateral or bilateral reproductive matrix haemorrhage, can be excluded from association studies as a condition with low genetic impact [52]. A significant advantage in terms of the research conducted and the results obtained is that the study population is strictly defined and ethnically homogeneous.…”

Comprehensive Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Retinopathy of Prematurity: A Study in the Polish Population

“…Current scientific reports suggest that the explanation of individual differences in susceptibility to ROP could be sought in the field of genetic background. Thus, many genetic studies on diseases in preterm infants, including ours, focus on key gene variants that enhance the inflammatory [8] or angiogenic [9,10] response and may contribute to an increased risk of preterm birth and complications of prematurity, such as ROP.…”