Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

Takeuchi, Hiroki; Natsume, Atsushi; Wakabayashi, Toshihiko; Aoshima, Chihiro; Shimato, Shinji; Ito, Motokazu; Ishii, Jun; Maeda, Yuka; Hara, Masahito; Kim, Seung Up; Yoshida, Jun

doi:10.1016/j.neulet.2007.08.048

Cited by 106 publications

(83 citation statements)

References 25 publications

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“…The current study found little expression of SDF-1 in the normal spinal cord, an increased level on day 1 post-injury, and the highest level on day 7 postinjury. This agrees with the results of a previous study (22). Only a small proportion of BMSCs expresses functionally active CXCR4 receptor on their surface and this expression diminished with passage, but CXCR4 is key to mediating specific migration of these cells (23,24).…”

Section: μM) (E)supporting

confidence: 92%

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury

Chen

Cui

et al. 2014

BST

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Section: μM) (E)supporting

confidence: 92%

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury

Chen

Cui

et al. 2014

BST

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“…The capacity of NSCs for CNS migration and neural cell differentiation makes these cells attractive resources for cell-based therapy, not only in EAE, but also in other types of neurodegenerative diseases (32,33). Systemic and i.c.v.…”

Section: Discussionmentioning

confidence: 99%

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Yang¹,

Jiang²,

Fitzgerald³

et al. 2009

J. Clin. Invest.

182

179

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“…NPCs injected systemically into healthy animals were in fact never found in the CNS, while exclusively accumulating (and persisting only for a short period) in peripheral organs (Pluchino et al, 2003). Specific homing of transplanted NPCs has been shown, so far, in experimental brain stroke (Chu et al, 2003;Lindvall and Kokaia, 2011), SCI (Takeuchi et al, 2007), epilepsy (Chu et al, 2004;Hattiangady et al, 2008), HD (Lee et al, 2006), and glioblastoma (Aboody et al, 2000;Ahmed et al, 2011).…”

Section: Homing and Extravasationmentioning

confidence: 99%

How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

108

109

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Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non-hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the interpretation of some of the outcomes ambiguous. In fact, the initial idea that stem cell transplants work only via structural cell replacement has been challenged by the observation of consistent cellular signaling between the graft and the host. Cellular signaling is the foundation of coordinated actions and flexible responses, and arises via networks of exchanging and interacting molecules that transmit patterns of information between cells. Sustained stem cell graft-to-host communication leads to remarkable trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses in vivo, ultimately promoting the healing of the injured CNS. Among a number of adult stem cell types, mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs) are being extensively investigated for their ability to signal to the immune system upon transplantation in experimental CNS diseases. Here, we focus on the main cellular signaling pathways that grafted MSCs and NPCs use to establish a therapeutically relevant cross talk with host immune cells, while examining the role of inflammation in regulating some of the bidirectionality of these communications. We propose that the identification of the players involved in stem cell signaling might contribute to the development of innovative, high clinical impact therapeutics for inflammatory CNS diseases.

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Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

Cited by 106 publications

References 25 publications

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

How stem cells speak with host immune cells in inflammatory brain diseases

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