Intravenously Infused Substance P Is Unable to Change Basal and TRH-Stimulated PRL Secretion in Normal Men

Coiro, V.; Volpi, R.; Capretti, L.; Caiazza, A.; Caffarri, G.; Rossi, G.; Marchesi, Carlo; Chiodera, P.

doi:10.1159/000182699

Cited by 4 publications

(2 citation statements)

References 10 publications

(13 reference statements)

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“…It is not known if this dose is physiological. An insufficient stimulus to lactotropes may also have been provided by SP infusion (1.5 pmol/kg/min) in men [50]. …”

Section: Discussionmentioning

confidence: 99%

Substance P-Immunoreactive Cells in the Ovine Pars Tuberalis

et al. 2008

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The pars tuberalis (PT) is a distinct subdivision of the anterior pituitary gland that plays a central role in regulating seasonal prolactin release. In sheep, there is compelling evidence that seasonal changes in light, transformed into a melatonin signal, are interpreted by the PT to modulate the release of a factor which affects prolactin release. The identity of this factor(s) is unknown but has been preemptively called ‘tuberalin’. In the present study, we report on an initial immunocytochemical investigation where we have identified that many ovine PT cells are immunoreactive for the tachykinin substance P (SP). Few cells in the pars distalis immunoreact for SP. The SP-immunoreactive cells did not colocalize with β-luteinizing hormone. RT-PCR confirmed the presence of preprotachykinin A mRNA in the PT. We hypothesize that SP, and possibly other preprotachykinin A-derived tachykinins, may play a role in the seasonal regulation of prolactin secretion in sheep.

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“…It is not known if this dose is physiological. An insufficient stimulus to lactotropes may also have been provided by SP infusion (1.5 pmol/kg/min) in men [50]. …”

Section: Discussionmentioning

confidence: 99%

Substance P-Immunoreactive Cells in the Ovine Pars Tuberalis

et al. 2008

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“…Challenge tests with SP have been used to investigate effects on CNS functions in healthy humans (Coiro et al, 1992(Coiro et al, , 1993. SP given intravenously increased secretion of ACTH and cortisol in a dose dependent manner (Coiro et al, 1992) and induced mood changes and sleep disturbances (Lieb et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effects of substance P on memory and mood in healthy male subjects

Herpfer¹,

Katzev²,

Feige³

et al. 2007

Human Psychopharmacology

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There is evidence from human and animal studies that substance P (SP) is involved in the etiopathology of depression and anxiety. Furthermore, animal studies have shown effects of SP on memory. In a double-blind, randomized cross-over study, 13 healthy young men received SP (1.5 pmol/kg/min) or placebo (NaCl) intravenously over 90 min at two different days. Before and during the infusion, symptoms of anxiety and depression were assessed by different self-rating questionnaires and cognitive functioning by the Auditory-Verbal Learning Test (AVLT) as well as by two subtests of the Test for Attentional Performance (TAP). Infusion of SP caused an increase of symptoms of inner tension and of anxiety as assessed by the Acute Panic Inventory (API) and a disturbance of short-term memory in the AVLT. The results may be interpreted as evidence for an anxiogenic and memory-disturbing effect of SP. Further studies will focus on the effects of SP in patients with depression, anxiety and cognitive disorders.

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