Effects of substance P on memory and mood in healthy male subjects

Herpfer, Inga; Katzev, Michael; Feige, Bernd; Fiebich, Bernd L.; Voderholzer, Ulrich; Lieb, Klaus

doi:10.1002/hup.876

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…43,44 Otherwise, probiotic strains might be able to act on the reduction of substance P in the gut, 45 since it was shown that alterations to the normal gut microbiota can increase substance P release in the nervous system and promote behaviors reflective of anxiety, depression and aggression. 46,47…”

Section: Possible Underlying Mechanismsmentioning

confidence: 99%

Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticusR0052 andBifidobacterium longumR0175) in healthy human volunteers

Messaoudi¹,

Violle²,

Bisson³

et al. 2011

Gut Microbes

462

280

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I n a recent clinical study, we demonstrated in the general population that Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (PF) taken in combination for 30 days decreased the global scores of hospital anxiety and depression scale (HADs), and the global severity index of the Hopkins symptoms checklist (HSCL-90), due to the decrease of the sub-scores of somatization, depression and angerhostility spheres. Therefore, oral intake of PF showed beneficial effects on anxiety and depression related behaviors in human volunteers. From there, it is interesting to focus on the role of this probiotic formulation in the subjects with the lowest urinary free cortisol levels at baseline. This addendum presents a secondary analysis of the effects of PF in a subpopulation of 25 subjects with urinary free cortisol (UFC) levels less than 50 ng/ml at baseline, on psychological distress based on the percentage of change of the perceived stress scale (PSs), the HADs and the HSCL-90 scores between baseline and follow-up. The data show that PF improves the same scores as in the general population (the HADs global score, the global severity index of the HSCL-90 and three of its sub-scores, i.e., somatization, depression and anger-hostility), as well as the PSs score and three other subscores of the HSCL-90, i.e., "obsessive compulsive," "anxiety" and "paranoidideation." Moreover, in the HSCL-90, Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers

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Section: Possible Underlying Mechanismsmentioning

confidence: 99%

Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticusR0052 andBifidobacterium longumR0175) in healthy human volunteers

Messaoudi¹,

Violle²,

Bisson³

et al. 2011

Gut Microbes

462

280

View full text Add to dashboard Cite

show abstract

“…Experimental alterations to the normal gut microbiota can increase substance P release in the nervous system and promote behaviors reflective of anxiety [85]. Indeed, even minute elevations in circulating substance P can lead to anxiety, depression and aggression [86]. Conversely, those who respond to antidepressant pharmacotherapy are known to have declines in serum substance P in conjunction with improved mood states [87].…”

Section: Introductionmentioning

confidence: 99%

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Bowe

Logan²

2011

Gut Pathog

200

146

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Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne.

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“…Experimental alterations to the normal gut microbiota can increase substance P release in the nervous system and promote behaviors reflective of anxiety [80]. Indeed, even very slight elevations in circulating substance P can lead to anxiety, depression and aggression [81]. Conversely, those who respond to antidepressant pharmacotherapy are known to have declines in serum substance P in conjunction with improved mood states [82].…”

Section: Introductionmentioning

confidence: 99%

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

2013

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Rapid scientific and technological advances have allowed for a more detailed understanding of the relevance of intestinal microbiota, and the entire body-wide microbiome, to human health and well-being. Rodent studies have provided suggestive evidence that probiotics (e.g. lactobacillus and bifidobacteria) can influence behavior. More importantly, emerging clinical studies indicate that the administration of beneficial microbes, via supplementation and/or fecal microbial transplant (FMT), can influence end-points related to mood state (glycemic control, oxidative status, uremic toxins), brain function (functional magnetic resonance imaging fMRI), and mental outlook (depression, anxiety). However, despite the advances in the area of gastro-biological psychiatry, it becomes clear that there remains an urgent need to explore the value of beneficial microbes in controlled clinical investigations. With the history explored in this series, it is fair to ask if we are now on the cusp of major clinical breakthroughs, or are we merely in the quicksand of Autointoxication II?

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Effects of substance P on memory and mood in healthy male subjects

Cited by 16 publications

References 37 publications

Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticusR0052 andBifidobacterium longumR0175) in healthy human volunteers

Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticusR0052 andBifidobacterium longumR0175) in healthy human volunteers

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

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