Intravenously infused substance P enhances basal and growth hormone (GH) releasing hormone-stimulated GH secretion in normal men

Coiro, V.; Volpi, R.; Capretti, L.; Speroni, G.; Bocchi, R.; Caffarri, G.; Colla, Rossana; Rossi, G.; Chiodera, P.

doi:10.1016/0196-9781(92)90195-9

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…This difference might be explained by the different time points at which SP was administered. In contrast to our study, in the studies of Coiro et al on SP-induced ACTH-and cortisol-secretion (Coiro et al 1992a) and SP-induced GH-secretion (Coiro et al 1992b), SP was administered at 9:00 A.M. Nevertheless, our results confirm the finding of Coiro et al (1992a) that SP stimulates cortisol secretion.…”

Section: Discussioncontrasting

confidence: 56%

“…Further studies should investigate effects of SP on ACTH and cortisol secretion in depressed patients. Our finding of a trend for lower levels of GH during the SP-infusion night is in contrast to the study of Coiro et al (1992b) who found that SP enhances basal and GHRH-stimulated GH secretion in normal men. This result could again be due to the different application time points (during the night in our study and in the morning in the study of Coiro et al 1992b).…”

Section: Discussioncontrasting

confidence: 56%

“…Our finding of a trend for lower levels of GH during the SP-infusion night is in contrast to the study of Coiro et al (1992b) who found that SP enhances basal and GHRH-stimulated GH secretion in normal men. This result could again be due to the different application time points (during the night in our study and in the morning in the study of Coiro et al 1992b). Our result of a sleep-associated blunting of GH-secretion by SP, however, is similar to the finding of disturbed GHsecretion in depressed patients (Jarrett et al 1990;Steiger et al 1993;Voderholzer et al 1993).…”

Section: Discussioncontrasting

confidence: 56%

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Effects of the Neuropeptide Substance P on Sleep, Mood, and Neuroendocrine Measures in Healthy Young Men

Lieb

Ahlvers

Dancker

et al. 2002

Neuropsychopharmacology

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Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 56%

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Effects of the Neuropeptide Substance P on Sleep, Mood, and Neuroendocrine Measures in Healthy Young Men

Lieb

Ahlvers

Dancker

et al. 2002

Neuropsychopharmacology

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“…In this context, it seems appropriate to include SP as a possible participant in the priming/activation of PMN, in spite of the fact that plasma levels of SP were not changed. SP is associated with tyrosine phosphorylation of a number of proteins , it stimulates ROS and RNS formation (Serra et al 1994;Sterner-Kock et al 1999) and enhances GH secretion (Coiro et al 1992). The lack of an immediate post-exercise increase of the CL at 1630 hours ( Fig.…”

Section: Discussionmentioning

confidence: 97%

Chemiluminescence response of granulocytes from elite athletes during recovery from one or two intense bouts of exercise

Bøyum

Rønsen²,

et al. 2002

European Journal of Applied Physiology

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In this study nine elite athletes each participated in three different 24- h trials, as follows: (1) complete bed rest (REST), (2) one bout of exercise at 1515 hours (ONE-EX), (3) two exercise bouts, one at 1100 hours and one at 1515 hours (TWO-EX-3 h), and (4) two exercise bouts, one at 0800 hours and one at 1515 hours (TWO-EX-6 h). Exercise was performed on a cycle ergometer with 10 min of warm-up and then 65 min at an exercise intensity of 75% of maximum oxygen uptake (VO(2max)). The polymorphonuclear neutrophil (PMN) counts increased consistently in response to exercise, and more in trial TWO-EX-3 h than in the two other exercise trials (P < 0.01). The respiratory burst of PMN was measured as chemiluminescence (CL), obtained with phorbol myristate (PMA) and serum-opsonised zymosan (SOZ) as stimulators. Exercise triggered the CL response for a defined number of PMN, significantly above baseline (REST) values (P < 0.05) for ONE-EX and TWO-EX-3 h, but not for TWO-EX-6 h. The strongest response was observed for TWO-EX-3 h, but the difference between exercise procedures was not significant. However, as a novel approach, a comparison was made using total oxidative potentials per litre of blood, as obtained by combining CL values and PMN numbers. TWO-EX-3 h yielded significantly higher values than the other experimental treatments. Thus, by this measure the total oxidative potential of PMN x l(-1) blood remains at a higher level with short intervals between exercise bouts (i.e. 3 h instead of 6 h), possibly due to a combined effect of cell number increase and the priming state of PMN. This may suggest that for intensive training twice a day, a recovery phase of 5-6 h is preferable. The elevation in cell number is best explained by a combined effect of catecholamines and cortisol. Growth hormone is one probable candidate as a stimulator of CL, but other molecular participants that respond to exercise may exert roles as either stimulators or inhibitors of CL.

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“…SP was given in a range of doses (0.5-1.5 pmol/kg-'/min-1) that did not produce stressful side effects and/or variations in blood pressure [1], In these experimental conditions, SP stimulated arginine vasopressin but not oxytocin secretion from the posterior pituitary [2], and G H [3]. A CT H [4] and LH [5] secretion from the anterior pituitary.…”

Section: Introductionmentioning

confidence: 99%

Intravenously Infused Substance P Is Unable to Change Basal and TRH-Stimulated PRL Secretion in Normal Men

Coiro

Volpi²,

Capretti³

et al. 1993

Horm Res

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In order to test the possible effects of an intravenous administration of substance P (SP) on basal and TRH-stimulated PRL release, SP was infused alone (0.5 or 1.5 pmol/kg^-1/min^-1 for 60 min) or after TRH (20 or 400 µg in an i.v. bolus) in 21 normal male subjects. In addition, plasma cortisol levels during SP infusion were measured. In agreement with previous findings, a significant increase in plasma cortisol levels was observed when the higher (1.5pmol/ kg^-1/min^-1) but not the lower (0.5 pmol/kg^-1/min^-1) amount of SP was given. In contrast, basal and TRH (20 or 400 µg)-induced PRL release were not modified by SP at any tested amount. These data suggest that, in normal men, plasma SP is not involved in the control of PRL release at the anterior pituitary level.

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Intravenously infused substance P enhances basal and growth hormone (GH) releasing hormone-stimulated GH secretion in normal men

Cited by 17 publications

References 14 publications

Effects of the Neuropeptide Substance P on Sleep, Mood, and Neuroendocrine Measures in Healthy Young Men

Effects of the Neuropeptide Substance P on Sleep, Mood, and Neuroendocrine Measures in Healthy Young Men

Chemiluminescence response of granulocytes from elite athletes during recovery from one or two intense bouts of exercise

Intravenously Infused Substance P Is Unable to Change Basal and TRH-Stimulated PRL Secretion in Normal Men

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